Psychosis superspectrum II: neurobiology, treatment, and implications
Alternatives to traditional categorical diagnoses have been proposed to improve the validity
and utility of psychiatric nosology. This paper continues the companion review of an …
and utility of psychiatric nosology. This paper continues the companion review of an …
A meta-analysis and systematic review of single vs. multimodal neuroimaging techniques in the classification of psychosis
Background Psychotic disorders are characterized by structural and functional abnormalities
in brain networks. Neuroimaging techniques map and characterize such abnormalities using …
in brain networks. Neuroimaging techniques map and characterize such abnormalities using …
Closing the life-cycle of normative modeling using federated hierarchical Bayesian regression
Clinical neuroimaging data availability has grown substantially in the last decade, providing
the potential for studying heterogeneity in clinical cohorts on a previously unprecedented …
the potential for studying heterogeneity in clinical cohorts on a previously unprecedented …
Characterization of the extracellular free water signal in schizophrenia using multi-site diffusion MRI harmonization
Abstract Studies applying Free Water Imaging have consistently reported significant global
increases in extracellular free water (FW) in populations of individuals with early psychosis …
increases in extracellular free water (FW) in populations of individuals with early psychosis …
Cognitive deficits, clinical variables, and white matter microstructure in schizophrenia: a multisite harmonization study
J Seitz-Holland, JD Wojcik, S Cetin-Karayumak… - Molecular …, 2022 - nature.com
Cognitive deficits are among the best predictors of real-world functioning in schizophrenia.
However, our understanding of how cognitive deficits relate to neuropathology and clinical …
However, our understanding of how cognitive deficits relate to neuropathology and clinical …
Schizophrenia and psychedelic state: Dysconnection versus hyper-connection. A perspective on two different models of psychosis stemming from dysfunctional …
Psychotic symptoms are a cross-sectional dimension affecting multiple diagnostic
categories, despite schizophrenia represents the prototype of psychoses. Initially, dopamine …
categories, despite schizophrenia represents the prototype of psychoses. Initially, dopamine …
Serum cortisol and insulin-like growth factor 1 levels in major depressive disorder and schizophrenia
H Arinami, Y Watanabe, Y Suzuki, M Tajiri… - Scientific Reports, 2023 - nature.com
The pathophysiology underlying major depressive disorder (MDD) and schizophrenia is
related to endocrine system functions and includes changes in the blood levels of cortisol …
related to endocrine system functions and includes changes in the blood levels of cortisol …
Matrix metalloproteinase 9 (MMP-9) activity, hippocampal extracellular free water, and cognitive deficits are associated with each other in early phase psychosis
Increasing evidence points toward the role of the extracellular matrix, specifically matrix
metalloproteinase 9 (MMP-9), in the pathophysiology of psychosis. MMP-9 is a critical …
metalloproteinase 9 (MMP-9), in the pathophysiology of psychosis. MMP-9 is a critical …
Treatment-resistant schizophrenia: Addressing white matter integrity, intracortical glutamate levels, clinical and cognitive profiles between early-and adult-onset …
M Matrone, GD Kotzalidis, A Romano, A Bozzao… - Progress in Neuro …, 2022 - Elsevier
Background Treatment-resistance in schizophrenia is 30–40%. Its neurobiology remains
unclear; to explore it, we conducted a combined spectrometry/tractography/cognitive battery …
unclear; to explore it, we conducted a combined spectrometry/tractography/cognitive battery …
Harmonized diffusion MRI data and white matter measures from the Adolescent Brain Cognitive Development Study
Abstract The Adolescent Brain Cognitive Development (ABCD) Study® has collected data
from over 10,000 children across 21 sites, providing insights into adolescent brain …
from over 10,000 children across 21 sites, providing insights into adolescent brain …