Neuroinflammation in Alzheimer disease

MT Heneka, WM van der Flier, F Jessen… - Nature Reviews …, 2024‏ - nature.com
Increasing evidence points to a pivotal role of immune processes in the pathogenesis of
Alzheimer disease, which is the most prevalent neurodegenerative and dementia-causing …

The neuroimmune axis of Alzheimer's disease

M Jorfi, A Maaser-Hecker, RE Tanzi - Genome Medicine, 2023‏ - Springer
Alzheimer's disease (AD) is a genetically complex and heterogeneous disorder with
multifaceted neuropathological features, including β-amyloid plaques, neurofibrillary …

Single-cell atlas reveals correlates of high cognitive function, dementia, and resilience to Alzheimer's disease pathology

H Mathys, Z Peng, CA Boix, MB Victor, N Leary, S Babu… - Cell, 2023‏ - cell.com
Alzheimer's disease (AD) is the most common cause of dementia worldwide, but the
molecular and cellular mechanisms underlying cognitive impairment remain poorly …

Amyloid and tau PET-positive cognitively unimpaired individuals are at high risk for future cognitive decline

R Ossenkoppele, A Pichet Binette, C Groot, R Smith… - Nature medicine, 2022‏ - nature.com
A major unanswered question in the dementia field is whether cognitively unimpaired
individuals who harbor both Alzheimer's disease neuropathological hallmarks (that is …

Tau and neuroinflammation in Alzheimer's disease: interplay mechanisms and clinical translation

Y Chen, Y Yu - Journal of neuroinflammation, 2023‏ - Springer
Alzheimer's Disease (AD) contributes to most cases of dementia. Its prominent
neuropathological features are the extracellular neuritic plaques and intercellular …

Microbiota from Alzheimer's patients induce deficits in cognition and hippocampal neurogenesis

S Grabrucker, M Marizzoni, E Silajdžić, N Lopizzo… - Brain, 2023‏ - academic.oup.com
Alzheimer's disease is a complex neurodegenerative disorder leading to a decline in
cognitive function and mental health. Recent research has positioned the gut microbiota as …

Neuroinflammation in Alzheimer's disease: current progress in molecular signaling and therapeutics

S Thakur, R Dhapola, P Sarma, B Medhi, DHK Reddy - Inflammation, 2023‏ - Springer
Alzheimer's disease, a neurodegenerative disease with amyloid beta accumulation as a
major hallmark, has become a dire global health concern as there is a lack of clear …

The amyloid cascade hypothesis: an updated critical review

KP Kepp, NK Robakis, PF Høilund-Carlsen, SL Sensi… - Brain, 2023‏ - academic.oup.com
Results from recent clinical trials of antibodies that target amyloid-β (Aβ) for Alzheimer's
disease have created excitement and have been heralded as corroboration of the amyloid …

Gut microbiome–brain alliance: a landscape view into mental and gastrointestinal health and disorders

JM Sasso, RM Ammar, R Tenchov… - ACS Chemical …, 2023‏ - ACS Publications
Gut microbiota includes a vast collection of microorganisms residing within the
gastrointestinal tract. It is broadly recognized that the gut and brain are in constant …

Oxidative stress: The core pathogenesis and mechanism of Alzheimer's disease

R Bai, J Guo, XY Ye, Y **e, T **e - Ageing research reviews, 2022‏ - Elsevier
As the number of patients with Alzheimer's disease (AD) increases, it brings great suffering
to their families and causes a heavy socioeconomic burden to society. A vast amount of …