Abstract Kinases of the Jak ('Janus kinase') family and transcription factors (TFs) of the STAT
('signal transducer and activator of transcription') family constitute a rapid membrane-to …

More than 50 cytokines signal via the JAK/STAT pathway to orchestrate hematopoiesis,
induce inflammation and control the immune response. Cytokines are secreted …

The Janus kinase/signal transduction and activator of transcription (JAK–STAT) signaling
pathway is implicated in the pathogenesis of inflammatory and autoimmune diseases …

Universal and essential to cytokine receptor signaling, the JAK-STAT pathway is one of the
best understood signal transduction cascades. Almost 40 cytokine receptors signal through …

Interferon-γ (IFN-γ) is an important mediator of immunity and inflammation that utilizes the
JAK-STAT signaling pathway to activate the STAT1 transcription factor. Many functions of …

Cytokines play a central role in the pathophysiology of autoimmune and inflammatory
diseases. Several cytokines signal through the JAK-STAT pathway, which is now recognized …

Interferon-γ is a cytokine whose biological activity is conventionally associated with
cytostatic/cytotoxic and antitumor mechanisms during cell-mediated adaptive immune …

The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway
serves as a paradigm for signal transduction from the extracellular environment to the …

The signal transducer and activator of transcription (STAT) 1 protein plays a key role in the
immune response against viruses and other pathogens by transducing, in the nucleus, the …

Background We performed a population-based study to describe the impact of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on pregnancy outcomes …