Pathological pain and the neuroimmune interface
Reciprocal signalling between immunocompetent cells in the central nervous system (CNS)
has emerged as a key phenomenon underpinning pathological and chronic pain …
has emerged as a key phenomenon underpinning pathological and chronic pain …
Exploring the neuroimmunopharmacology of opioids: an integrative review of mechanisms of central immune signaling and their implications for opioid analgesia
Vastly stimulated by the discovery of opioid receptors in the early 1970s, preclinical and
clinical research was directed at the study of stereoselective neuronal actions of opioids …
clinical research was directed at the study of stereoselective neuronal actions of opioids …
Microglia control neuronal network excitability via BDNF signalling
Microglia‐neuron interactions play a crucial role in several neurological disorders
characterized by altered neural network excitability, such as epilepsy and neuropathic pain …
characterized by altered neural network excitability, such as epilepsy and neuropathic pain …
Emerging role of Toll-like receptors in the control of pain and itch
Toll-like receptors (TLRs) are germline-encoded pattern-recognition receptors that initiate
innate immune responses by recognizing molecular structures shared by a wide range of …
innate immune responses by recognizing molecular structures shared by a wide range of …
Toll-like receptors in chronic pain
L Nicotra, LC Loram, LR Watkins, MR Hutchinson - Experimental neurology, 2012 - Elsevier
Proinflammatory central immune signaling contributes significantly to the initiation and
maintenance of heightened pain states. Recent discoveries have implicated the innate …
maintenance of heightened pain states. Recent discoveries have implicated the innate …
Calcitonin gene-related peptide is a key neurotransmitter in the neuro-immune axis
BM Assas, JI Pennock, JA Miyan - Frontiers in neuroscience, 2014 - frontiersin.org
The question of how the neural and immune systems interact in host defense is important,
integrating a system that senses the whole body with one that protects. Understanding the …
integrating a system that senses the whole body with one that protects. Understanding the …
Priming of adult pain responses by neonatal pain experience: maintenance by central neuroimmune activity
Adult brain connectivity is shaped by the balance of sensory inputs in early life. In the case of
pain pathways, it is less clear whether nociceptive inputs in infancy can have a lasting …
pain pathways, it is less clear whether nociceptive inputs in infancy can have a lasting …
[HTML][HTML] Bioactive lipids and their derivatives in biomedical applications
Lipids, which along with carbohydrates and proteins are among the most important nutrients
for the living organism, have a variety of biological functions that can be applied widely in …
for the living organism, have a variety of biological functions that can be applied widely in …
Dexmedetomidine Inhibits Inflammatory Reaction in Lung Tissues of Septic Rats by Suppressing TLR4/NF‐κB Pathway
Y Wu, Y Liu, H Huang, Y Zhu, Y Zhang… - Mediators of …, 2013 - Wiley Online Library
Dexmedetomidine has been reported to reduce mortality in septic rats. This study was
designed to investigate the effects of dexmedetomidine on inflammatory reaction in lung …
designed to investigate the effects of dexmedetomidine on inflammatory reaction in lung …
Adolescent morphine exposure affects long-term microglial function and later-life relapse liability in a model of addiction
Adolescence in humans represents a unique developmental time point associated with
increased risk-taking behavior and experimentation with drugs of abuse. We hypothesized …
increased risk-taking behavior and experimentation with drugs of abuse. We hypothesized …