Fracture healing is a complex event that involves the coordination of a variety of different
processes. Repair is typically characterized by four overlap** stages: the initial …

The intimate connection, both physical and biochemical, between blood vessels and bone
cells has long been recognized. Genetic, biochemical, and pharmacological studies have …

Therapeutic growth factor delivery typically requires supraphysiological dosages, which can
cause undesirable off-target effects. The aim of this study was to 3D bioprint implants …

Bone regeneration is a coordinated cascade of events regulated by several cytokines and
growth factors. Angiogenic growth factors are predominantly expressed during the early …

This study investigated the effects of dual delivery of vascular endothelial growth factor
(VEGF) and bone morphogenetic protein-2 (BMP-2) for bone regeneration in a rat cranial …

More than 100 years ago Wilhelm Roux (1895) introduced the term “functional adaptation to
anatomy and physiology”. Compared with other organ systems the functional adaptation …

A major limitation with current tissue‐engineering approaches is creating functionally
vascularized constructs that can successfully integrate with the host; this often leads to …

The two growth factors VEGF and PDGF are involved in the process of bone regeneration.
For this reason, we developed a brushite–chitosan system which controls the release …

Objective Bone regeneration involves a coordinated cascade of events that are regulated by
several cytokines and growth factors, among which bone morphogenic protein-2 (BMP-2) …

Fracture healing is a natural process that recapitulates embryonic skeletal development. In
the early phase after fracture, reactive oxygen species (ROS) are produced under …