Many types of cell show different aspects of polarization. Epithelial cells display a ubiquitous
apical–basolateral polarity but often are also polarized in the plane of the epithelium–a …

A key aspect of animal development is the appropriate polarisation of different cell types in
the right place at the right time. Such polarisation is often precisely coordinated relative to …

Hippo signaling controls organ size by regulating cell proliferation and apoptosis. Yes‐
associated protein (YAP) is a key downstream effector of Hippo signaling, and LATS …

This FlyBook chapter summarizes the history and the current state of our understanding of
the Wingless signaling pathway. Wingless, the fly homolog of the mammalian Wnt …

The bone morphogenetic protein (BMP) signalling pathway is critical for embryonic
development and tissue homeostasis, and impaired BMP signalling has been implicated in …

The canonical Wnt signalling pathway is essential for cell fate determination during
embryonic development and for the maintenance of adult tissue homeostasis. Deregulation …

The Wnt/Wingless (Wg) pathway represents a conserved signaling cascade involved in
diverse biological processes. Misregulation of Wnt/Wg signal transduction has profound …

Wnt/β-catenin signaling regulates many aspects of early vertebrate development, including
patterning of the mesoderm and neurectoderm during gastrulation. In zebrafish, Wnt …

The Drosophila circadian oscillator is comprised of transcriptional feedback loops that are
activated by CLOCK (CLK) and CYCLE (CYC) and repressed by PERIOD (PER) and …

Drosophila Nemo is the founding member of the Nemo-like kinase (Nlk) family of
serine/threonine protein kinases that are involved in several Wnt signal transduction …