Correlates of protection (CoPs) are increasingly important in the development and licensure
of vaccines. Although the study of CoPs was initially directed at identifying a single immune …

In vitro-transcribed, messenger RNA-based infectious disease vaccines have the potential to
successfully address many of the weaknesses of traditional vaccine platforms, such as the …

Background Reoccurring Ebola outbreaks in West and Central Africa have led to serious
illness and death in thousands of adults and children. The objective of this study was to …

It has been proven challenging to conduct traditional efficacy trials for Ebola virus (EBOV)
vaccines. In the absence of efficacy data, immunobridging is an approach to infer the …

Correlates of protection (CoP) are biological parameters that predict a certain level of
protection against an infectious disease. Well-established correlates of protection facilitate …

Preventative vaccines are considered one of the most cost-effective and efficient means to
contain outbreaks and prevent pandemics. However, the requirements to gain licensure and …

Although substantial progress has been made with Ebola virus (EBOV) vaccine measures,
the immune correlates of vaccine-mediated protection remain uncertain. Here, five mucosal …

Summary The 2013 Ebola epidemic in Central and West Africa heralded the emergence of
wide-spread, highly pathogenic viruses. The successful recombinant vector vaccine against …

Ebola virus (EBOV) glycoprotein (GP) can be recognized by neutralizing antibodies (NAbs)
and is the main target for vaccine design. Here, we first investigate the contribution of the …

Health emergencies caused by epidemic-prone pathogens (EPPs) have increased
exponentially in recent decades. Although vaccines have proven beneficial, they are …