Improving head and neck cancer therapies by immunomodulation of the tumour microenvironment
Targeted immunotherapy has improved patient survival in head and neck squamous cell
carcinoma (HNSCC), but less than 20% of patients produce a durable response to these …
carcinoma (HNSCC), but less than 20% of patients produce a durable response to these …
B cell function in the tumor microenvironment
The tumor microenvironment (TME) is a heterogeneous, complex organization composed of
tumor, stroma, and endothelial cells that is characterized by cross talk between tumor and …
tumor, stroma, and endothelial cells that is characterized by cross talk between tumor and …
Functional Th1-oriented T follicular helper cells that infiltrate human breast cancer promote effective adaptive immunity
G Noël, ML Fontsa, S Garaud… - The Journal of …, 2021 - Am Soc Clin Investig
We previously demonstrated that tumor-infiltrating lymphocytes (TIL) in human breast cancer
sometimes form organized tertiary lymphoid structures (TLS) characterized by CXCL13 …
sometimes form organized tertiary lymphoid structures (TLS) characterized by CXCL13 …
[HTML][HTML] Role of tumor infiltrating lymphocytes and spatial immune heterogeneity in sensitivity to PD-1 axis blockers in non-small cell lung cancer
Background Tumor infiltrating lymphocytes (TILs) reflect adaptive antitumor immune
responses in cancer and are generally associated with favorable prognosis. However, the …
responses in cancer and are generally associated with favorable prognosis. However, the …
Progenitor-like exhausted SPRY1+ CD8+ T cells potentiate responsiveness to neoadjuvant PD-1 blockade in esophageal squamous cell carcinoma
Neoadjuvant immune checkpoint blockade (ICB) demonstrates promise in operable
esophageal squamous cell carcinoma (ESCC), but lacks available efficacy biomarkers …
esophageal squamous cell carcinoma (ESCC), but lacks available efficacy biomarkers …
Spatial transcriptomics technology in cancer research
In recent years, spatial transcriptomics (ST) technologies have developed rapidly and have
been widely used in constructing spatial tissue atlases and characterizing spatiotemporal …
been widely used in constructing spatial tissue atlases and characterizing spatiotemporal …
Nanovaccines fostering tertiary lymphoid structure to attack mimicry nasopharyngeal carcinoma
Z Wen, H Liu, D Qiao, H Chen, L Li, Z Yang, C Zhu… - ACS …, 2023 - ACS Publications
Tertiary lymphoid structures (TLSs) are formed in inflamed tissues, and recent studies
demonstrated that the appearance of TLSs in tumor sites is associated with a good …
demonstrated that the appearance of TLSs in tumor sites is associated with a good …
The presence of tertiary lymphoid structures provides new insight into the clinicopathological features and prognosis of patients with breast cancer
B Wang, J Liu, Y Han, Y Deng, J Li, Y Jiang - Frontiers in immunology, 2022 - frontiersin.org
Background Tertiary lymphoid structures (TLSs) have been proven to be predictive
biomarkers of favorable clinical outcomes and response to immunotherapies in several solid …
biomarkers of favorable clinical outcomes and response to immunotherapies in several solid …
Activation of B cells in Tertiary Lymphoid Structures in cancer: Anti-tumor or anti-self?
Whereas T cells in the tumor microenvironment have been the main focus as cancer
controlling cells and targets of immunotherapies, B cells have recently gained strong …
controlling cells and targets of immunotherapies, B cells have recently gained strong …
Germinal center-dependent and-independent immune responses of tumor-infiltrating B cells in human cancers
B cells play essential roles in immunity, mainly through the production of high affinity plasma
cells (PCs) and memory B (Bmem) cells. The affinity maturation and differentiation of B cells …
cells (PCs) and memory B (Bmem) cells. The affinity maturation and differentiation of B cells …