Mechanism and regulation of the nonsense-mediated decay pathway
N Hug, D Longman, JF Cáceres - Nucleic acids research, 2016 - academic.oup.com
The Nonsense-mediated mRNA decay (NMD) pathway selectively degrades mRNAs
harboring premature termination codons (PTCs) but also regulates the abundance of a large …
harboring premature termination codons (PTCs) but also regulates the abundance of a large …
Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease
Alzheimer's disease (AD) is the most common dementing disorder of late life. Although there
might be various different triggering events in the early stages of the disease, they seem to …
might be various different triggering events in the early stages of the disease, they seem to …
Genome-wide map** of alternative splicing in Arabidopsis thaliana
Alternative splicing can enhance transcriptome plasticity and proteome diversity. In plants,
alternative splicing can be manifested at different developmental stages, and is frequently …
alternative splicing can be manifested at different developmental stages, and is frequently …
Nonsense-mediated mRNA decay—mechanisms of substrate mRNA recognition and degradation in mammalian cells
C Schweingruber, SC Rufener, D Zünd… - … et Biophysica Acta (BBA …, 2013 - Elsevier
The nonsense-mediated mRNA decay (NMD) pathway is well known as a translation-
coupled quality control system that recognizes and degrades aberrant mRNAs with …
coupled quality control system that recognizes and degrades aberrant mRNAs with …
STIM1 Mutation Associated with a Syndrome of Immunodeficiency and Autoimmunity
C Picard, CA McCarl, A Papolos, S Khalil… - … England Journal of …, 2009 - Mass Medical Soc
A mutation in ORAI1, the gene encoding the pore-forming subunit of the Ca2+-release–
activated Ca2+ (CRAC) channel, abrogates the store-operated entry of Ca2+ into cells and …
activated Ca2+ (CRAC) channel, abrogates the store-operated entry of Ca2+ into cells and …
Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin
Hereditary persistence of fetal hemoglobin (HPFH) is characterized by persistent high levels
of fetal hemoglobin (HbF) in adults. Several contributory factors, both genetic and …
of fetal hemoglobin (HbF) in adults. Several contributory factors, both genetic and …
Molecular basis of a shattering resistance boosting global dissemination of soybean
H Funatsuki, M Suzuki, A Hirose… - Proceedings of the …, 2014 - National Acad Sciences
Pod dehiscence (shattering) is essential for the propagation of wild plant species bearing
seeds in pods but is a major cause of yield loss in legume and crucifer crops. Although …
seeds in pods but is a major cause of yield loss in legume and crucifer crops. Although …
SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells
AB Eberle, S Lykke-Andersen, O Mühlemann… - Nature structural & …, 2009 - nature.com
From yeast to humans, mRNAs harboring premature termination codons (PTCs) are
recognized and degraded by nonsense-mediated mRNA decay (NMD). However …
recognized and degraded by nonsense-mediated mRNA decay (NMD). However …
Beyond quality control: The role of nonsense-mediated mRNA decay (NMD) in regulating gene expression
S Nasif, L Contu, O Mühlemann - Seminars in cell & developmental biology, 2018 - Elsevier
Nonsense-mediated mRNA decay (NMD) has traditionally been described as a quality
control system that rids cells of aberrant mRNAs with crippled protein coding potential …
control system that rids cells of aberrant mRNAs with crippled protein coding potential …
Nonsense-mediated mRNA decay in human cells: mechanistic insights, functions beyond quality control and the double-life of NMD factors
P Nicholson, H Yepiskoposyan, S Metze… - Cellular and molecular …, 2010 - Springer
Nonsense-mediated decay is well known by the lucid definition of being a RNA surveillance
mechanism that ensures the speedy degradation of mRNAs containing premature …
mechanism that ensures the speedy degradation of mRNAs containing premature …