Nemaline myopathy (NM) is among the most common non-dystrophic congenital
myopathies (incidence 1: 50.000). Hallmark features of NM are skeletal muscle weakness …

Acute heart failure (HF) and in particular, cardiogenic shock are associated with high
morbidity and mortality. A therapeutic dilemma is that the use of positive inotropic agents …

Istaroxime, an intravenous inotropic agent with a dual mechanism—increasing both
cardiomyocyte contractility and relaxation—is a novel treatment for acute heart failure (AHF) …

Cardiac troponin C (cTnC) is the regulatory protein that initiates cardiac contraction in
response to Ca 2+. TnC binding Ca 2+ initiates a cascade of protein–protein interactions …

The sarcomere is the functional unit of cardiac muscle, essential for normal heart function.
To date, it has not been possible to study, in real time, thin filament-based activation …

The binding of Ca2+ to cardiac troponin C (cTnC) triggers contraction in heart muscle. In the
diseased heart, the myocardium is often desensitized to Ca2+, which leads to impaired …

One approach to improve contraction in the failing heart is the administration of calcium (Ca
2+) sensitizers. Although it is known that levosimendan and other sensitizers bind to …

The objective was to investigate and evaluate the short-term efficacy and safety of
levosimendan in patients with chronic systolic heart failure. Forty-nine patients with chronic …

Several studies have suggested that conformational dynamics are important in the
regulation of thin filament activation in cardiac troponin C (cTnC); however, little direct …

Cardiomyopathies (CM) are the leading cause of death in America, and can develop from
mutations in sarcomeric proteins, leading to altered protein structure and function. Current …