Metronomic chemotherapy describes the close, regular administration of chemotherapy
drugs at less-toxic doses over prolonged periods of time. In 2015, the results of randomized …

Low-dose metronomic (LDM) chemotherapy, the frequent and continuous use of low doses
of conventional chemotherapeutics, is an emerging alternative to conventional …

The introduction of the “maximum tolerated dose” in usual treatment protocols (and its
concomitant overt toxicity) made necessary the imposition of rest periods between cycles of …

The oxazaphosphorines including cyclophosphamide (CPA), ifosfamide (IFO), and
trofosfamide represent an important group of therapeutic agents due to their substantial …

Purpose To investigate the activity of letrozole plus/minus oral metronomic
cyclophophamide as primary systemic treatment (PST) in elderly breast cancer patients …

Metronomic (low-dose, long-term and frequently administered) chemotherapy has attracted
renewed interest for the past few years, in particular because of possible positive …

The oxazaphosphorine cyclophosphamide (CPA) and ifosfamide (IFO) are two commonly
used DNAalkylating agents in cancer chemotherapy. This review highlights the …

Metronomic chemotherapy (MCT), characterized by the continuous administration of
chemotherapeutics at a lower dose without prolonged drug-free periods, has garnered …

The development of cancer vaccines based on tumor-associated antigens is hurdled by lack
of an efficient adjuvant and insufficient efficacy. To improve the efficacy of vaccines, a …

Metronomic chemotherapy has emerged as a compelling and innovative therapeutic
approach in the management of breast cancer. This chapter highlights the application of …