Immunity to fungal infections

L Romani - Nature Reviews Immunology, 2011 - nature.com
Fungal diseases represent an important paradigm in immunology, as they can result from
either a lack of recognition by the immune system or overactivation of the inflammatory …

Race and ethnicity: Risk factors for fungal infections?

JD Jenks, CI Aneke, MM Al-Obaidi, M Egger… - PLoS …, 2023 - journals.plos.org
Racial and ethnic identities, largely understood as social rather than biologic constructs,
may impact risk for acquiring infectious diseases, including fungal infections. Risk factors …

Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient-and donor …

C Cunha, M Di Ianni, S Bozza… - Blood, The Journal …, 2010 - ashpublications.org
The C-type lectin receptor Dectin-1 plays a pivotal role in antifungal immunity. In this study,
the recently characterized human DECTIN1 Y238X early stop codon polymorphism leading …

Important aspects of Toll-like receptors, ligands and their signaling pathways

ZL Chang - Inflammation research, 2010 - Springer
Due to the rapid increase of new information on the multiple roles of Toll-like receptors
(TLRs), this paper reviews several main properties of TLRs and their ligands and signaling …

Epidemiology and treatment approaches in management of invasive fungal infections

J Kriengkauykiat, JI Ito, SS Dadwal - Clinical epidemiology, 2011 - Taylor & Francis
Over the past 20 years, the number of invasive fungal infections has continued to persist,
due primarily to the increased numbers of patients subjected to severe immunosuppression …

TLR3 essentially promotes protective class I–restricted memory CD8+ T-cell responses to Aspergillus fumigatus in hematopoietic transplanted patients

A Carvalho, A De Luca, S Bozza… - Blood, The Journal …, 2012 - ashpublications.org
Aspergillus fumigatus is a model fungal pathogen and a common cause of severe infections
and diseases. CD8+ T cells are present in the human and murine T-cell repertoire to the …

Invasive fungal disease and cytomegalovirus infection: is there an association?

MK Yong, MA Slavin… - Current opinion in …, 2018 - journals.lww.com
CMV infection is associated with increased risk of IFD in posttransplant recipients because
of a number of overlap** and virus-specific risk factors. Better understanding of how CMV …

Association of TLR1, TLR2, TLR4, TLR6, and TIRAP polymorphisms with disease susceptibility

M Noreen, M Arshad - Immunologic Research, 2015 - Springer
Toll like receptors (TLRs) play a crucial role in regulation of innate as well as adaptive
immunity. TLRs recognize a distinct but limited repertoire of conserved microbial products …

Human NK cells and herpesviruses: mechanisms of recognition, response and adaptation

M Della Chiesa, A De Maria, L Muccio… - Frontiers in …, 2019 - frontiersin.org
NK cells contribute to early defenses against viruses through their inborn abilities that
include sensing of PAMPs and inflammatory signals such as cytokines or chemokines …

The Y238X stop codon polymorphism in the human β-glucan receptor dectin-1 and susceptibility to invasive aspergillosis

LYA Chai, MGJ de Boer… - Journal of Infectious …, 2011 - academic.oup.com
Background. Dectin-1 is the major receptor for fungal β-glucans on myeloid cells. We
investigated whether defective Dectin-1 receptor function, because of the early stop codon …