Roadmap: helium ion therapy

A Mairani, S Mein, E Blakely, J Debus… - Physics in Medicine …, 2022 - iopscience.iop.org
Helium ion beam therapy for the treatment of cancer was one of several developed and
studied particle treatments in the 1950s, leading to clinical trials beginning in 1975 at the …

Dose calculation algorithms for external radiation therapy: an overview for practitioners

F De Martino, S Clemente, C Graeff, G Palma, L Cella - Applied sciences, 2021 - mdpi.com
Featured Application Radiation therapy treatment planning. Abstract Radiation therapy (RT)
is a constantly evolving therapeutic technique; improvements are continuously being …

[HTML][HTML] Commissioning of helium ion therapy and the first patient treatment with active beam delivery

T Tessonnier, S Ecker, J Besuglow, J Naumann… - International Journal of …, 2023 - Elsevier
Purpose: Helium ions offer intermediate physical and biological properties to the clinically
used protons and carbon ions. This work presents the commissioning of the first clinical …

[HTML][HTML] Development and validation of single field multi-ion particle therapy treatments

B Kopp, S Mein, I Dokic, S Harrabi, TT Böhlen… - International Journal of …, 2020 - Elsevier
Purpose To develop and validate combined ion-beam with constant relative biological
effectiveness (RBE)(CICR) particle therapy in single field arrangements for improved …

Assessment of RBE-weighted dose models for carbon ion therapy toward modernization of clinical practice at HIT: in vitro, in vivo, and in patients

S Mein, C Klein, B Kopp, G Magro, S Harrabi… - International Journal of …, 2020 - Elsevier
Purpose Present-day treatment planning in carbon ion therapy is conducted with
assumptions for a limited number of tissue types and models for effective dose. Here, we …

[HTML][HTML] Particle arc therapy: Status and potential

S Mein, S Wuyckens, X Li, S Both, A Carabe… - Radiotherapy and …, 2024 - Elsevier
There is a rising interest in develo** and utilizing arc delivery techniques with charged
particle beams, eg, proton, carbon or other ions, for clinical implementation. In this work …

Towards harmonizing clinical linear energy transfer (LET) reporting in proton radiotherapy: a European multi-centric study

C Hahn, J Ödén, A Dasu, A Vestergaard… - Acta …, 2022 - Taylor & Francis
Background Clinical data suggest that the relative biological effectiveness (RBE) in proton
therapy (PT) varies with linear energy transfer (LET). However, LET calculations are neither …

Biophysical modeling and experimental validation of relative biological effectiveness (RBE) for 4He ion beam therapy

S Mein, I Dokic, C Klein, T Tessonnier, TT Böhlen… - Radiation …, 2019 - Springer
Abstract Background Helium (4 He) ion beam therapy provides favorable biophysical
characteristics compared to currently administered particle therapies, ie, reduced lateral …

[HTML][HTML] Spot-scanning hadron arc (SHArc) therapy: a study with light and heavy ions

S Mein, T Tessonnier, B Kopp, S Harrabi… - Advances in radiation …, 2021 - Elsevier
Purpose To evaluate the clinical potential of spot-scanning hadron arc (SHArc) therapy with
a heavy-ion gantry. Methods and Materials A series of in silico studies was conducted via …

Challenges in Monte Carlo simulations as clinical and research tool in particle therapy: a review

S Muraro, G Battistoni, AC Kraan - Frontiers in Physics, 2020 - frontiersin.org
The use and interest in Monte Carlo (MC) techniques in the field of medical physics have
been rapidly increasing in the past years. This is the case especially in particle therapy …