Members of the Notch family of transmembrane receptors play an important role in cell fate
determination. Over the past decade, a role for Notch in the pathogenesis of hematologic …

Notch proteins regulate a broad spectrum of cell fate decisions and differentiation processes
during fetal and postnatal development. Mammals have four Notch receptors that bind five …

High serum levels of IL-6 correlate with poor outcome in breast cancer patients. However, no
data are available on the relationship between IL-6 and mammary stem/progenitor cells …

Notch signals are necessary for the functional outcomes of T cell receptor β-selection,
including differentiation, proliferation and rescue from apoptosis. The mechanism underlying …

Primary immunodeficiencies (PIDs) provide researchers with unique models to understand
in vivo immune responses in general and immunity to infections in particular. In humans …

Abstract The chromosomal translocation t (7; 9) in human T-cell acute lymphoblastic
leukaemia (T-ALL) results in deregulated expression of a truncated, activated form of Notch …

Signals transduced by Notch receptors are indispensable for T cell specification and
differentiation of αβ T lineage cells. However, the role of Notch signals during αβ versus γδ T …

Recent discoveries indicate that gain-of-function mutations in the Notch1 receptor are very
common in human T cell acute lymphoblastic leukemia/lymphoma. This review discusses …

Constitutive Notch activation is required for the proliferation of a subgroup of T-cell acute
lymphoblastic leukemia (T-ALL). Downstream pathways that transmit pro-oncogenic signals …

Background—Activated macrophages contribute to the pathogenesis of inflammatory
diseases such as atherosclerosis. Although Notch signaling participates in various aspects …