The voltage-gated sodium, calcium, and potassium channels are responsible for the
generation of conducted electrical signals in neurons and other excitable cells. The …

I. OVERVIEW AND NOMENCLATURE Times change. In 1926, the writer of a review in this
journal noted that over 350 papers had appeared on the subject during the previous 2 years …

Gabapentin (1-(aminomethyl) cyclohexane acetic acid; Neurontin) is a novel anticonvulsant
drug, with a mechanism of action apparently dissimilar to that of other antiepileptic agents …

The architecture of the junctional sarcoplasmic reticulum (SR) and transverse tubule (T
tubule) membranes and the morphology of the two major proteins isolated from these …

Purified dihydropyridine-sensitive calcium channels from rabbit transverse-tubule
membranes consist of three noncovalently associated classes of subunits: alpha (167 kDa) …

Voltage-sensitive ion channels mediate action potentials in electrically excitable cells and
play important roles in signal transduction in other cell types. In the past several years, their …

Recent investigations have demonstrated that neurons have a number of different types of
calcium channels, each with their own unique properties and pharmacology. These calcium …

It is common to experience a thum** heart during strenuous exercise or when frightened.
This increase in the force and frequency of contraction of the heart can result in an increase …

Many excitable cells contain at least two different voltage-dependent Ca channels (L-and T-
type) 1–3. The cardiac, slow, L-type Ca channel is further modulated by cyclic AMP …

Calcium channels are known to exist in muscle, neuronal and secretory cells. The 1, 4-
dihydropyridines are potent blockers of L-type Ca e+ channels, and have been used as …