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A review on omics-based biomarkers discovery for Alzheimer's disease from the bioinformatics perspectives: statistical approach vs machine learning approach
Alzheimer's Disease (AD) is a neurodegenerative disease that affects cognition and is the
most common cause of dementia in the elderly. As the number of elderly individuals …
most common cause of dementia in the elderly. As the number of elderly individuals …
Exploring biomarkers for Alzheimer's disease
N Sharma, AN Singh - Journal of clinical and diagnostic …, 2016 - pmc.ncbi.nlm.nih.gov
Alzheimer's Disease (AD) is one of the most common form of dementia occurring in elderly
population worldwide. Currently Aβ42, tau and p-tau in the cerebrospinal fluid is estimated …
population worldwide. Currently Aβ42, tau and p-tau in the cerebrospinal fluid is estimated …
Predicting early Alzheimer's with blood biomarkers and clinical features
ME AlMansoori, S Jemimah, F Abuhantash… - Scientific Reports, 2024 - nature.com
Alzheimer's disease (AD) is an incurable neurodegenerative disorder that leads to
dementia. This study employs explainable machine learning models to detect dementia …
dementia. This study employs explainable machine learning models to detect dementia …
[HTML][HTML] Ubiquitin ligase COP1 suppresses neuroinflammation by degrading c/EBPβ in microglia
Dysregulated microglia are intimately involved in neurodegeneration, including Alzheimer's
disease (AD) pathogenesis, but the mechanisms controlling pathogenic microglial gene …
disease (AD) pathogenesis, but the mechanisms controlling pathogenic microglial gene …
Two glycosyltransferases involved in anthocyanin modification delineated by transcriptome independent component analysis in Arabidopsis thaliana
K Yonekura‐Sakakibara, A Fukushima… - The Plant …, 2012 - Wiley Online Library
To identify candidate genes involved in Arabidopsis flavonoid biosynthesis, we applied
transcriptome coexpression analysis and independent component analyses with 1388 …
transcriptome coexpression analysis and independent component analyses with 1388 …
The epigenetic landscape of Alzheimer's disease
Two independent epigenome-wide association studies of Alzheimer's disease cohorts have
identified overlap** methylation signals in four loci, ANK1, RPL13, RHBDF2 and CDH23 …
identified overlap** methylation signals in four loci, ANK1, RPL13, RHBDF2 and CDH23 …
Identification of differentially expressed genes through integrated study of Alzheimer's disease affected brain regions
Background Alzheimer's disease (AD) is the most common form of dementia in older adults
that damages the brain and results in impaired memory, thinking and behaviour. The …
that damages the brain and results in impaired memory, thinking and behaviour. The …
Cell-type-specific expression quantitative trait loci associated with Alzheimer disease in blood and brain tissue
Because regulation of gene expression is heritable and context-dependent, we investigated
AD-related gene expression patterns in cell types in blood and brain. Cis-expression …
AD-related gene expression patterns in cell types in blood and brain. Cis-expression …
Physiological and pathophysiological roles for phospholipase D
RK Nelson, MA Frohman - Journal of lipid research, 2015 - pmc.ncbi.nlm.nih.gov
Individual members of the mammalian phospholipase D (PLD) superfamily undertake roles
that extend from generating the second messenger signaling lipid, phosphatidic acid …
that extend from generating the second messenger signaling lipid, phosphatidic acid …
Simple model systems reveal conserved mechanisms of Alzheimer's disease and related tauopathies
The lack of effective therapies that slow the progression of Alzheimer's disease (AD) and
related tauopathies highlights the need for a more comprehensive understanding of the …
related tauopathies highlights the need for a more comprehensive understanding of the …