Despite efficient combination of the antiretroviral therapy (cART), which significantly
decreased mortality and morbidity of HIV-1 infection, a definitive HIV cure has not been …

One of the most explored therapeutic approaches aimed at eradicating HIV-1 reservoirs is
the “shock and kill” strategy which is based on HIV-1 reactivation in latently-infected cells …

Although HIV-1 replication can be efficiently suppressed to undetectable levels in peripheral
blood by combination antiretroviral therapy (cART), lifelong medication is still required in …

HIV-1 employs a rich arsenal of viral factors throughout its life cycle and co-opts intracellular
trafficking pathways. This exquisitely coordinated process requires precise manipulation of …

The most studied HIV eradication approach is the “shock and kill” strategy, which aims to
reactivate the latent reservoir by latency reversing agents (LRAs) and allowing elimination of …

The Human Immunodeficiency Virus (HIV) encodes several proteins that contort the host cell
environment to promote viral replication and spread. This is often accomplished through the …

Vpr is a lentiviral accessory protein that is expressed late during the infection cycle and is
packaged in significant quantities into virus particles through a specific interaction with the …

The conjugation of small ubiquitin-like modifier (SUMO) proteins to substrates is a well-
described post-translational modification that regulates protein activity, subcellular …

Nucleoporins (NUPs) are cellular effectors of human immunodeficiency virus-1 (HIV-1)
replication that support nucleocytoplasmic trafficking of viral components. However, these …

HIV-1 encodes four accesory proteins in addition to its structural and regulatory genes.
Uniquely amongst them, Vpr is abundantly present within virions, meaning it is poised to …