Resistance of cancer cells to anticancer drugs remains a major challenge in modern
medicine. Understanding the mechanisms behind the development of chemoresistance is …

Recent data suggest that most genotoxic agents in cancer therapy can lead to shock of
genome and increase in cell size, which leads whole genome duplication or multiplication …

Docetaxel (DTX) combined with cisplatin and 5-fluorouracil has been used as induction
chemotherapy for head and neck squamous cell carcinoma (HNSCC). However, the …

We are tremendously excited to share with you this special issue on Polyploidy,
Senescence, Evolution, and Cancer. Polyploidy is known to play an important role in …

Considerable evidence suggests that breast cancer therapeutic resistance and relapse can
be driven by polyploid giant cancer cells (PGCCs). The number of PGCCs increases with the …

The emergence of chemotherapy resistance drives cancer lethality in cancer patients, with
treatment initially reducing overall tumor burden followed by resistant recurrent disease …

Chemoresistance is a major cause of treatment failure in many cancers. However, the life
cycle of cancer cells as they respond to and survive environmental and therapeutic stress is …

Tumour cell dormancy is critical for metastasis and resistance to chemoradiotherapy.
Polyploid giant cancer cells (PGCCs) with giant or multiple nuclei and high DNA content …

Background Pathological complete response (pCR) is associated with favorable prognosis
in patients with triple-negative breast cancer (TNBC). However, only 30–40% of TNBC …

Artificial Intelligence (AI) has emerged as a transformative tool in predicting metastasis risk
and survival outcomes in cancer care. Traditional methods for assessing cancer progression …