Vigor, effort-related aspects of motivation and anhedonia
In this chapter we provide an overview of the pharmacological and circuit mechanisms that
determine the willingness to expend effort in pursuit of rewards. A particular focus will be on …
determine the willingness to expend effort in pursuit of rewards. A particular focus will be on …
Behavioral and dopamine transporter binding properties of the modafinil analog (S, S)-CE-158: reversal of the motivational effects of tetrabenazine and …
Rationale Atypical dopamine (DA) transport blockers such as modafinil and its analogs may
be useful for treating motivational symptoms of depression and other disorders. Previous …
be useful for treating motivational symptoms of depression and other disorders. Previous …
Effects of the atypical antipsychotic and D3/D2 dopamine partial agonist cariprazine on effort-based choice behavior: implications for modeling avolition
Rationale Cariprazine is an atypical antipsychotic that acts as a D3/D2 receptor partial
agonist. In addition to treating positive symptoms of schizophrenia, cariprazine may have …
agonist. In addition to treating positive symptoms of schizophrenia, cariprazine may have …
Effort-related effects of chronic administration of the DA D2 receptor antagonist haloperidol via subcutaneous programmable minipumps: Reversal by co …
Rationale Long-acting antipsychotics such as haloperidol decanoate are becoming more
commonly used. Long-acting depot formulations have several advantages, but secondary …
commonly used. Long-acting depot formulations have several advantages, but secondary …
The dopamine depleting agent tetrabenazine alters effort-related decision making as assessed by mouse touchscreen procedures
Rationale Effort-based decision-making tasks allow animals to choose between preferred
reinforcers that require high effort to obtain vs. low-effort/low reward options. Mesolimbic …
reinforcers that require high effort to obtain vs. low-effort/low reward options. Mesolimbic …
Pharmacological characterization of sex differences in the effects of dopaminergic drugs on effort-based decision making in rats
A Ecevitoglu, KR Beard, S Srynath, GA Edelstein… - …, 2024 - Springer
Objectives Previous rodent studies mainly employed male rats, and it is imperative to
conduct studies in male and female rats. Methods The present studies compared the effort …
conduct studies in male and female rats. Methods The present studies compared the effort …
Comparison of acute treatment with delayed-onset versus rapid-acting antidepressants on effort-related choice behaviour
Rationale Reward-related impairments are common in major depressive disorder (MDD)
and may contribute to the loss of interest in pleasurable activities. A novel approach to …
and may contribute to the loss of interest in pleasurable activities. A novel approach to …