The burden of cardiovascular and metabolic diseases worldwide is staggering. The
emergence of systems approaches in biology promises new therapies, faster and cheaper …

Head development in vertebrates involves a complex series of molecular and
morphogenetic events that generate a coordinated pattern of cartilages, bones and nerves …

We show that high doses of salicylates reverse hyperglycemia, hyperinsulinemia, and
dyslipidemia in obese rodents by sensitizing insulin signaling. Activation or overexpression …

Systematic genome-wide mutagenesis screens for embryonic phenotypes have been
instrumental in the understanding of invertebrate and plant development. Here, we report …

The zebrafish has become one of the most important model organisms to study biologial
processes in vivo. As a vertebrate that has many of the strengths of invertebrate model …

As part of a large-scale mutagenesis screen of the zebrafish genome, we have identified 58
mutations that affect the formation and function of the cardiovascular system. The …

The zebrafish (Danio rerio) has emerged as an appreciated and versatile model organism
for studying cardiovascular and metabolic diseases, offering unique advantages for both …

To rapidly identify genes required for early vertebrate development, we are carrying out a
large-scale, insertional mutagenesis screen in zebrafish, using mouse retroviral vectors as …

The formation of the face and skull involves a complex series of developmental events
mediated by cells derived from the neural crest, endoderm, mesoderm, and ectoderm …

The neural crest (NC) is a major contributor to the vertebrate craniofacial skeleton, detailed
in model organisms through embryological and genetic approaches, most notably in chick …