Intracellular complement and immunometabolism: The advantages of compartmentalization
BC King, AM Blom - European Journal of Immunology, 2024 - Wiley Online Library
The complement system is a proteolytic cascade triggered by pathogen and danger‐
associated molecular patterns, with resultant outcomes of inflammation, cellular activation …
associated molecular patterns, with resultant outcomes of inflammation, cellular activation …
C5aR1 antagonism suppresses inflammatory glial responses and alters cellular signaling in an Alzheimer's disease mouse model
Alzheimer's disease (AD) is the leading cause of dementia in older adults, and the need for
effective, sustainable therapeutic targets is imperative. The complement pathway has been …
effective, sustainable therapeutic targets is imperative. The complement pathway has been …
Fungal Influences on Cancer Initiation, Progression, and Response to Treatment
Fungal dysbiosis is increasingly recognized as a key factor in cancer, influencing tumor
initiation, progression, and treatment outcomes. This review explores the role of fungi in …
initiation, progression, and treatment outcomes. This review explores the role of fungi in …
The complement system: A key player in the host response to infections
A Jayaraman, S Walachowski… - European Journal of …, 2024 - Wiley Online Library
Infections are one of the most significant healthcare and economic burdens across the world
as underscored by the recent coronavirus pandemic. Moreover, with the increasing …
as underscored by the recent coronavirus pandemic. Moreover, with the increasing …
mSphere of Influence: Complement activity beyond systemic circulation—implications in the context of infections
JV Desai - mSphere, 2025 - journals.asm.org
Jigar V. Desai works in the field of immunology, studying the mucosal and systemic
complement systems and their roles in regulating the immune response. In this mSphere of …
complement systems and their roles in regulating the immune response. In this mSphere of …
C5aR1 inhibition alleviates cranial radiation-induced cognitive decline
RP Krattli, AH Do, SM El-Khatib, L Alikhani… - bioRxiv, 2024 - biorxiv.org
Cranial radiation therapy (RT) for brain cancers leads to an irreversible decline in cognitive
function without an available remedy. Radiation-induced cognitive deficits (RICD) are a …
function without an available remedy. Radiation-induced cognitive deficits (RICD) are a …
Complement and fungal diseases
JV Desai, MS Lionakis - The Journal of allergy and …, 2025 - pubmed.ncbi.nlm.nih.gov
Journal Pre-proof Complement and fungal diseases Jigar V. Desai, PhD, Michail S.
Lionakis, MD, ScD PII: S0091-6749 (25) 00165-4 DOI: https://doi. org/10.1016/j. jaci …
Lionakis, MD, ScD PII: S0091-6749 (25) 00165-4 DOI: https://doi. org/10.1016/j. jaci …