Regeneration is one of the great mysteries of biology. Planarians are flatworms capable of
dramatic feats of regeneration, which have been studied for over 2 centuries. Recent …

▪ Abstract The principles underlying regeneration in planarians have been explored for over
100 years through surgical manipulations and cellular observations. Planarian regeneration …

Pluripotent cells in the embryo can generate all cell types, but lineage-restricted cells are
generally thought to replenish adult tissues. Planarians are flatworms and regenerate from …

Freshwater planarians were a classic model for studying the problems of development and
regeneration. However, as attention shifted towards animals with more rigid developmental …

Planarians are members of the Platyhelminthes (flatworms). These animals have evolved a
remarkable stem cell system. A single pluripotent adult stem cell type (“neoblast”) gives rise …

The singular regenerative abilities of planarians require a population of stem cells known as
neoblasts. In response to wounding, or during the course of cell turnover, neoblasts are …

Regeneration requires signaling from a wound site for detection of the wound and a
mechanism that determines the nature of the injury to specify the appropriate regenerative …

Planarians are a group of flatworms. Some planarian species have remarkable regenerative
abilities, which involve abundant pluripotent adult stem cells. This makes these worms a …

In adult planarians, the replacement of cells lost to physiological turnover or injury is
sustained by the proliferation and differentiation of stem cells known as neoblasts. Neoblast …

Many long-lived organisms, including humans, can regenerate some adult tissues lost to
physical injury or disease. Much of the previous research on mechanisms of regeneration …