Influenza A virus polymerase: structural insights into replication and host adaptation mechanisms

S Boivin, S Cusack, RWH Ruigrok, DJ Hart - Journal of Biological Chemistry, 2010 - ASBMB
The heterotrimeric RNA-dependent RNA polymerase of influenza viruses catalyzes RNA
replication and transcription activities in infected cell nuclei. The nucleotide polymerization …

CagA-mediated pathogenesis of Helicobacter pylori

A Tohidpour - Microbial pathogenesis, 2016 - Elsevier
Helicobacter pylori has been described as the main etiologic agent of gastric cancer,
causing a considerable rate of mortality and morbidity in human population across the world …

Helicobacter pylori Type IV Secretion Apparatus Exploits β1 Integrin in a Novel RGD-Independent Manner

LF Jiménez-Soto, S Kutter, X Sewald, C Ertl… - PLoS …, 2009 - journals.plos.org
Translocation of the Helicobacter pylori (Hp) cytotoxin-associated gene A (CagA) effector
protein via the cag-Type IV Secretion System (T4SS) into host cells is a major risk factor for …

Tertiary structure-function analysis reveals the pathogenic signaling potentiation mechanism of Helicobacter pylori oncogenic effector CagA

T Hayashi, M Senda, H Morohashi, H Higashi… - Cell host & …, 2012 - cell.com
The Helicobacter pylori type IV secretion effector CagA is a major bacterial virulence
determinant and critical for gastric carcinogenesis. Upon delivery into gastric epithelial cells …

Structural insights into Helicobacter pylori oncoprotein CagA interaction with β1 integrin

B Kaplan-Türköz, LF Jiménez-Soto… - Proceedings of the …, 2012 - National Acad Sciences
Infection with the gastric pathogen Helicobacter pylori is a risk factor for the development of
gastric cancer. Pathogenic strains of H. pylori carry a type IV secretion system (T4SS) …

Architecture of the Helicobacter pylori Cag‐type IV secretion system

L Terradot, G Waksman - The FEBS journal, 2011 - Wiley Online Library
Type IV secretion systems (T4SS) are macromolecular assemblies used by bacteria to
transport material across their membranes. T4SS are generally composed of a set of twelve …

Towards an atomic resolution understanding of the influenza virus replication machinery

RWH Ruigrok, T Crépin, DJ Hart, S Cusack - Current opinion in structural …, 2010 - Elsevier
The influenza polymerase transcribes and replicates the viral RNA genome within the
context of a ribonucleoprotein complex that has been hitherto remarkably intractable to …

Structural-dynamic insights into the H. pylori cytotoxin-associated gene A (CagA) and its abrogation to interact with the tumor suppressor protein ASPP2 using decoy …

M Junaid, M Shah, A Khan, CD Li… - Journal of …, 2019 - Taylor & Francis
Helicobacter pylori (H. pylori) is one of the most extensively studied Gram-negative bacteria
due to its implication in gastric cancer. The oncogenicity of H. pylori is associated with …

When is Helicobacter pylori acquired in populations in develo** countries? A birth-cohort study in Bangladeshi children

S Kienesberger, GI Perez-Perez, AZ Olivares… - Gut …, 2018 - Taylor & Francis
Helicobacter pylori colonization is prevalent throughout the world, and is predominantly
acquired during childhood. In develo** countries,> 70% of adult populations are …

ESPRIT: an automated, library-based method for map** and soluble expression of protein domains from challenging targets

H Yumerefendi, F Tarendeau, PJ Mas… - Journal of structural biology, 2010 - Elsevier
Expression of sufficient quantities of soluble protein for structural biology and other
applications is often a very difficult task, especially when multimilligram quantities are …