The physiological identity of every cell is maintained by highly specific transcriptional
networks that establish a coherent molecular program that is in tune with nutritional …

Astrocyte-neuron interactions protect neurons from iron-mediated toxicity. As dopamine can
be metabolized to reactive quinones, dopaminergic neurons are susceptible to oxidative …

Circadian dysfunction is a common attribute of many neurodegenerative diseases, most of
which are associated with neuroinflammation. Circadian rhythm dysfunction has been …

REV-ERB nuclear receptors are potent transcriptional repressors that play an important role
in the core mammalian molecular clock and metabolism. Deletion of both REV-ERBα and its …

Obesity is a major risk factor for the development of illnesses, such as insulin resistance and
hypertension, and has become a serious public health problem. Mammals have developed …

Rev-erbα is a nuclear receptor that links circadian rhythms to transcriptional control of
metabolic pathways. Rev-erbα is a potent transcriptional repressor and plays an important …

Aging is by far the most prominent risk factor for Alzheimer's disease (AD), and both aging
and AD are associated with apparent metabolic alterations. As develo** effective …

The mammalian circadian system is a hierarchically organized system, which controls a 24-
h periodicity in a wide variety of body and brain functions and physiological processes …

Time-of-day is a crucial, yet often overlooked, biological variable in biomedical research. We
examined the top 25 most cited papers in several domains of behavioral neuroscience to …

To design potentially more effective therapies, we need to further understand the
mechanisms underlying epilepsy. Here, we uncover the role of Rev-erbα in circadian …