The interferon-regulatory factor (IRF) family of transcription factors was initially found to be
involved in the induction of genes that encode type I interferons. IRFs have now been shown …

Interferon regulatory factors (IRFs) constitute a family of transcription factors that commonly
possess a novel helix-turn-helix DNA-binding motif. Following the initial identification of two …

Natural killer (NK) cells play critical roles defending against tumors and pathogens. We
show that mice lacking both transcription factors Eomesodermin (Eomes) and T-bet failed to …

Innate lymphoid cells (ILCs) play key roles in host defense, barrier integrity, and
homeostasis and mirror adaptive CD4+ T helper (Th) cell subtypes in both usage of effector …

The interferon regulatory factor (IRF) family, consisting of nine members in mammals, was
identified in the late 1980s in the context of research into the type I interferon system …

Abstract Interferon Regulatory Factors (IRFs), a family of transcription factors, profoundly
influence the immune system, impacting both physiological and pathological processes …

▪ Abstract The significance of type I interferons (IFN-α/β) in biology and medicine renders
research on their activities continuously relevant to our understanding of normal and …

Natural killer (NK) and CD1d-restricted Vα14i natural killer T (NKT) cells play a critical early
role in host defense. Here we show that mice with a targeted deletion of T-bet, a T-box …

Abstract Interferon-regulatory factor 4 (IRF4) is essential for the development of T helper type
2 cells. Here we show that IRF4 is also critical for the generation of interleukin 17–producing …

▪ Abstract Natural killer (NK) cells play important roles in immunological processes, including
early defense against viral infections. This review provides an overview of the dynamic in …