The impact of the gut microbiome on extra-intestinal autoimmune diseases

E Miyauchi, C Shimokawa, A Steimle… - Nature Reviews …, 2023 - nature.com
The prevalence of autoimmune diseases (ADs) worldwide has rapidly increased over the
past few decades. Thus, in addition to the classical risk factors for ADs, such as genetic …

Intestinal barrier in human health and disease

N Di Tommaso, A Gasbarrini, FR Ponziani - International journal of …, 2021 - mdpi.com
The intestinal mucosa provides a selective permeable barrier for nutrient absorption and
protection from external factors. It consists of epithelial cells, immune cells and their …

Gut microbiota and immune system interactions

JY Yoo, M Groer, SVO Dutra, A Sarkar, DI McSkimming - Microorganisms, 2020 - mdpi.com
Dynamic interactions between gut microbiota and a host's innate and adaptive immune
systems are essential in maintaining intestinal homeostasis and inhibiting inflammation. Gut …

Gut microbiota-derived metabolites in the regulation of host immune responses and immune-related inflammatory diseases

W Yang, Y Cong - Cellular & molecular immunology, 2021 - nature.com
The gut microbiota has a critical role in the maintenance of immune homeostasis. Alterations
in the intestinal microbiota and gut microbiota-derived metabolites have been recognized in …

The human gut microbiome–a potential controller of wellness and disease

ZY Kho, SK Lal - Frontiers in microbiology, 2018 - frontiersin.org
Interest toward the human microbiome, particularly gut microbiome has flourished in recent
decades owing to the rapidly advancing sequence-based screening and humanized …

Causal effects of gut microbiome on systemic lupus erythematosus: a two-sample Mendelian randomization study

K **ang, P Wang, Z Xu, YQ Hu, YS He, Y Chen… - Frontiers in …, 2021 - frontiersin.org
The observational association between gut microbiome and systemic lupus erythematosus
(SLE) has been well documented. However, whether the association is causal remains …

Elucidating the role of diet in maintaining gut health to reduce the risk of obesity, cardiovascular and other age-related inflammatory diseases: Recent challenges and …

T Aziz, N Hussain, Z Hameed, L Lin - Gut Microbes, 2024 - Taylor & Francis
ABSTRACT A healthy balanced diet is crucial in protecting the immune system against
infections and diseases. Poor diets, such as the Western diet, contribute to the development …

Microbial dysbiosis in the gut drives systemic autoimmune diseases

WK Mousa, F Chehadeh, S Husband - Frontiers in immunology, 2022 - frontiersin.org
Trillions of microbes survive and thrive inside the human body. These tiny creatures are
crucial to the development and maturation of our immune system and to maintain gut …

Lupus nephritis is linked to disease-activity associated expansions and immunity to a gut commensal

D Azzouz, A Omarbekova, A Heguy… - Annals of the …, 2019 - ard.bmj.com
Background/Purpose To search for a transmissible agent involved in lupus pathogenesis,
we investigated the faecal microbiota of patients with systemic lupus erythematosus (SLE) …

Crosstalk between gut microbiota and innate immunity and its implication in autoimmune diseases

Y Jiao, L Wu, ND Huntington, X Zhang - Frontiers in immunology, 2020 - frontiersin.org
The emerging concept of microbiota contributing to local mucosal homeostasis has fueled
investigation into its specific role in immunology. Gut microbiota is mostly responsible for …