Transposable elements (TEs) promote genetic innovation but also threaten genome stability.
Despite multiple layers of host defence, TEs actively shape mammalian-specific …

BACKGROUND Mammalian germ cells differentiate into oocytes in females and
spermatozoa in males. An oocyte and a spermatozoon fuse to form a zygote and then …

Genome editing is a powerful new tool for making precise alterations to an organism's
genetic material. Recent scientific advances have made genome editing more efficient …

The female germ line undergoes a unique sequence of differentiation processes that confers
totipotency to the egg,. The reconstitution of these events in vitro using pluripotent stem cells …

Mammalian eggs (oocytes) are formed during fetal life and establish associations with
somatic cells to form primordial follicles that create a store of germ cells (the primordial pool) …

Primordial germ cells (PGCs), the precursors of sperm and eggs, are established in
perigastrulation-stage embryos in mammals. Signals from extra-embryonic tissues induce a …

Dynamic pluripotent stem cell (PSC) states are in vitro adaptations of pluripotency
continuum in vivo. Previous studies have generated a number of PSCs with distinct …

Continuous spermatogenesis in post-pubertal mammals is dependent on spermatogonial
stem cells (SSCs), which balance self-renewing divisions that maintain stem cell pool with …

Sex chromosome disorders severely compromise gametogenesis in both males and
females. In oogenesis, the presence of an additional Y chromosome or the loss of an X …

Mechanisms underlying human germ cell development are unclear, partly due to difficulties
in studying human embryos and lack of suitable experimental systems. Here, we show that …