Cancer organoids 2.0: modelling the complexity of the tumour immune microenvironment
R Polak, ET Zhang, CJ Kuo - Nature Reviews Cancer, 2024 - nature.com
The development of neoplasia involves a complex and continuous interplay between
malignantly transformed cells and the tumour microenvironment (TME). Cancer …
malignantly transformed cells and the tumour microenvironment (TME). Cancer …
Roles of IFN-γ in tumor progression and regression: a review
D Jorgovanovic, M Song, L Wang, Y Zhang - Biomarker research, 2020 - Springer
Background Interferon-γ (IFN-γ) plays a key role in activation of cellular immunity and
subsequently, stimulation of antitumor immune-response. Based on its cytostatic, pro …
subsequently, stimulation of antitumor immune-response. Based on its cytostatic, pro …
[HTML][HTML] CXCR6 positions cytotoxic T cells to receive critical survival signals in the tumor microenvironment
Cytotoxic T lymphocyte (CTL) responses against tumors are maintained by stem-like
memory cells that self-renew but also give rise to effector-like cells. The latter gradually lose …
memory cells that self-renew but also give rise to effector-like cells. The latter gradually lose …
Regulatory T cells in tumor microenvironment: new mechanisms, potential therapeutic strategies and future prospects
C Li, P Jiang, S Wei, X Xu, J Wang - Molecular cancer, 2020 - Springer
Regulatory T cells (Tregs) characterized by the expression of the master transcription factor
forkhead box protein p3 (Foxp3) suppress anticancer immunity, thereby hindering protective …
forkhead box protein p3 (Foxp3) suppress anticancer immunity, thereby hindering protective …
Lipid signalling enforces functional specialization of Treg cells in tumours
Regulatory T cells (Treg cells) are essential for immune tolerance, but also drive
immunosuppression in the tumour microenvironment. Therapeutic targeting of Treg cells in …
immunosuppression in the tumour microenvironment. Therapeutic targeting of Treg cells in …
[HTML][HTML] Cancer immunotherapy: Pros, cons and beyond
S Tan, D Li, X Zhu - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Cancer immunotherapy is an innovative treatment for tumors today. In various experiments
and clinical studies, it has been found that immunotherapy does have incomparable …
and clinical studies, it has been found that immunotherapy does have incomparable …
T cell subsets and functions in atherosclerosis
Atherosclerosis is a chronic inflammatory disease of the arterial wall and the primary
underlying cause of cardiovascular disease. Data from in vivo imaging, cell-lineage tracing …
underlying cause of cardiovascular disease. Data from in vivo imaging, cell-lineage tracing …
Regulatory T cells and human disease
Naturally occurring CD4+ regulatory T cells (Tregs), which specifically express the
transcription factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface, are a …
transcription factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface, are a …
Lenvatinib targets FGF receptor 4 to enhance antitumor immune response of anti–programmed cell death‐1 in HCC
C Yi, L Chen, Z Lin, L Liu, W Shao, R Zhang, J Lin… - …, 2021 - Wiley Online Library
Background and Aims Recently, clinical trials of lenvatinib plus pembrolizumab in HCC have
displayed an impressive objective response rate. This study aimed to clarify the mechanism …
displayed an impressive objective response rate. This study aimed to clarify the mechanism …
Targeting Treg cells with GITR activation alleviates resistance to immunotherapy in murine glioblastomas
Immune checkpoint blockers (ICBs) have failed in all phase III glioblastoma (GBM) trials.
Here, we show that regulatory T (Treg) cells play a key role in GBM resistance to ICBs in …
Here, we show that regulatory T (Treg) cells play a key role in GBM resistance to ICBs in …