Some recent clinical and preclinical evidence suggests that neuroinflammation is a key
factor that interacts with the three neurobiological correlates of major depressive disorder …

The many facets of the oxytocin (OXT) system of the brain and periphery elicited nearly
25,000 publications since 1930 (see, as listed in PubMed), which revealed central roles for …

In response to a peripheral infection, innate immune cells produce pro-inflammatory
cytokines that act on the brain to cause sickness behaviour. When activation of the …

The neural networks that putatively modulate aspects of normal emotional behavior have
been implicated in the pathophysiology of mood disorders by converging evidence from …

Any physical or psychological stimuli that disrupt homeostasis result in a stress response.
The stimuli are called stressors, and physiological and behavioral changes in response to …

This review begins with a brief historical overview of attempts in the first half of the 20th
century to discern brain systems that underlie emotion and emotional behavior. These early …

Depression is highly common throughout the life course and dementia is common in late life.
Depression has been linked with dementia, and growing evidence implies that the timing of …

Aging is a natural process that is associated with cognitive decline as well as functional and
social impairments. One structure of particular interest when considering aging and …

Increasing numbers of studies have suggested that the gut microbiota is involved in the
pathophysiology of stress-related disorders. Chronic stress can cause behavioral, cognitive …

The hypothalamic–pituitary–adrenal (HPA) axis, a neuroendocrine network that controls
hormonal responses to internal and external challenges in an organism's environment …