[HTML][HTML] Nitrosative stress and human disease: Therapeutic potential of denitrosylation

S Yoon, GH Eom, G Kang - International journal of molecular sciences, 2021 - mdpi.com
Proteins dynamically contribute towards maintaining cellular homeostasis. Posttranslational
modification regulates the function of target proteins through their immediate activation …

Moderate exercise-induced dynamics on key sepsis-associated signaling pathways in the liver

HP Osuru, K Ikeda, N Atluri, RH Thiele - Critical Care, 2023 - Springer
Background There is a clear relationship between quantitative measures of fitness (eg, VO2
max) and outcomes after surgical procedures. Whether or not fitness is a modifiable risk …

Jejunal mucosa proteomics unravel metabolic adaptive processes to mild chronic heat stress in dairy cows

F Koch, D Albrecht, S Görs, B Kuhla - Scientific Reports, 2021 - nature.com
Climate change affects the duration and intensity of heat waves during summer months and
jeopardizes animal health and welfare. High ambient temperatures cause heat stress in …

Molecular and cellular response of the myocardium (H9C2 Cells) towards hypoxia and HIF-1α inhibition

HP Osuru, M Lavallee, RH Thiele - Frontiers in Cardiovascular …, 2022 - frontiersin.org
Introduction Oxidative phosphorylation is an essential feature of Animalian life. Multiple
adaptations have developed to protect against hypoxia, including hypoxia-inducible-factors …

An atlas of dynamic peripheral blood mononuclear cell landscapes in human perioperative anaesthesia/surgery

YY Wang, EQ Chang, RL Zhu, XZ Liu… - Clinical and …, 2022 - Wiley Online Library
Background The number of patients receiving anaesthesia is increasing, but the impact of
general anaesthesia on the patient's immune system remains unclear. The aim of the …

[HTML][HTML] Intraoperative administration of isoflurane improves survival in rats exposed to caecal ligation and puncture

K Ikeda, HP Osuru, RH Thiele - BJA open, 2022 - Elsevier
Background Emerging data suggest that volatile anaesthetic agents may be protective
during critical illness. Methods Three-month-old Sprague Dawley rats were randomly …

[PDF][PDF] RETRACTED: Dual One-Way Study of Sepsis Survivability Study in Rats Exposed to Cecal Ligation and Puncture with Propofol or Isoflurane

K Ikeda, HP Osuru, RH Thiele - 2021 - scholar.archive.org
BACKGROUND Several studies have also shown that short-term exposure to volatile
anesthetic agents (VAA) affects proin ammatory pathways such as the cytokine response …