Proactive and reactive roles of TGF-β in cancer

NA Kuburich, T Sabapathy, BR Demestichas… - Seminars in cancer …, 2023 - Elsevier
Cancer cells adapt to varying stress conditions to survive through plasticity. Stem cells
exhibit a high degree of plasticity, allowing them to generate more stem cells or differentiate …

Endocytosis and organelle targeting of nanomedicines in cancer therapy

X Wang, Y Qiu, M Wang, C Zhang, T Zhang… - International journal …, 2020 - Taylor & Francis
Nanomedicines (NMs) have played an increasing role in cancer therapy as carriers to
efficiently deliver therapeutics into tumor cells. For this application, the uptake of NMs by …

[HTML][HTML] Selective surface PEGylation of UiO-66 nanoparticles for enhanced stability, cell uptake, and pH-responsive drug delivery

IA Lazaro, S Haddad, S Sacca, C Orellana-Tavra… - Chem, 2017 - cell.com
The high storage capacities and excellent biocompatibilities of metal-organic frameworks
(MOFs) have made them emerging candidates as drug-delivery vectors. Incorporation of …

How cationic lipids transfer nucleic acids into cells and across cellular membranes: recent advances

Z ur Rehman, IS Zuhorn, D Hoekstra - Journal of Controlled Release, 2013 - Elsevier
Cationic lipid-and polymer-based nanodevices are considered appropriate alternatives for
virus-based particles for delivery of nucleic acids, including genes and siRNA, into …

Effects of serum adsorption on cellular uptake profile and consequent impact of titanium dioxide nanoparticles on human lung cell lines

R Tedja, M Lim, R Amal, C Marquis - ACS nano, 2012 - ACS Publications
Exposure to fetal bovine serum (FBS) is shown herein to reduce the aggregate size of
titanium dioxide (TiO2) nanoparticles, affecting uptake and consequent effect on A549 and …

[HTML][HTML] The pore-forming action of polyenes: From model membranes to living organisms

L Kristanc, B Božič, ŠZ Jokhadar, MS Dolenc… - … et Biophysica Acta (BBA …, 2019 - Elsevier
The incidence of resistant fungal pathogens has been increasing, especially in immuno-
compromised people. As such, considerable research has been focused on discovering anti …

Pathways of cellular internalisation of liposomes delivered siRNA and effects on siRNA engagement with target mRNA and silencing in cancer cells

A Alshehri, A Grabowska, S Stolnik - Scientific reports, 2018 - nature.com
Abstract Design of an efficient delivery system is a generally recognised bottleneck in
translation of siRNA technology into clinic. Despite research efforts, cellular processes that …

Ion exchange: an advanced synthetic method for complex nanoparticles

G Cho, Y Park, YK Hong, DH Ha - Nano Convergence, 2019 - Springer
There have been tremendous efforts to develop new synthetic methods for creating novel
nanoparticles (NPs) with enhanced and desired properties. Among the many synthetic …

Enterococcus faecalis alters endo-lysosomal trafficking to replicate and persist within mammalian cells

RAG da Silva, WH Tay, FK Ho, FR Tanoto… - PLoS …, 2022 - journals.plos.org
Enterococcus faecalis is a frequent opportunistic pathogen of wounds, whose infections are
associated with biofilm formation, persistence, and recalcitrance toward treatment. We have …

Cell penetrating peptide-modified poly (lactic-co-glycolic acid) nanoparticles with enhanced cell internalization

JM Steinbach, YE Seo, WM Saltzman - Acta biomaterialia, 2016 - Elsevier
The surface modification of nanoparticles (NPs) can enhance the intracellular delivery of
drugs, proteins, and genetic agents. Here we studied the effect of different surface ligands …