The speed-accuracy tradeoff: history, physiology, methodology, and behavior

RP Heitz - Frontiers in neuroscience, 2014 - frontiersin.org
There are few behavioral effects as ubiquitous as the speed-accuracy tradeoff (SAT). From
insects to rodents to primates, the tendency for decision speed to covary with decision …

The structural basis of inter-individual differences in human behaviour and cognition

R Kanai, G Rees - Nature Reviews Neuroscience, 2011 - nature.com
Inter-individual variability in perception, thought and action is frequently treated as a source
of'noise'in scientific investigations of the neural mechanisms that underlie these processes …

Representational drift in primary olfactory cortex

CE Schoonover, SN Ohashi, R Axel, AJP Fink - Nature, 2021 - nature.com
Perceptual constancy requires the brain to maintain a stable representation of sensory input.
In the olfactory system, activity in primary olfactory cortex (piriform cortex) is thought to …

A gradual temporal shift of dopamine responses mirrors the progression of temporal difference error in machine learning

R Amo, S Matias, A Yamanaka, KF Tanaka… - Nature …, 2022 - nature.com
A large body of evidence has indicated that the phasic responses of midbrain dopamine
neurons show a remarkable similarity to a type of teaching signal (temporal difference (TD) …

Dopamine neurons projecting to the posterior striatum reinforce avoidance of threatening stimuli

W Menegas, K Akiti, R Amo, N Uchida… - Nature …, 2018 - nature.com
Midbrain dopamine neurons are well known for their role in reward-based reinforcement
learning. We found that the activity of dopamine axons in the posterior tail of the striatum …

Demixed principal component analysis of neural population data

D Kobak, W Brendel, C Constantinidis, CE Feierstein… - elife, 2016 - elifesciences.org
Neurons in higher cortical areas, such as the prefrontal cortex, are often tuned to a variety of
sensory and motor variables, and are therefore said to display mixed selectivity. This …

A unified framework for dopamine signals across timescales

HGR Kim, AN Malik, JG Mikhael, P Bech… - Cell, 2020 - cell.com
Rapid phasic activity of midbrain dopamine neurons is thought to signal reward prediction
errors (RPEs), resembling temporal difference errors used in machine learning. However …

Dopamine facilitates associative memory encoding in the entorhinal cortex

JY Lee, H Jun, S Soma, T Nakazono, K Shiraiwa… - Nature, 2021 - nature.com
Mounting evidence shows that dopamine in the striatum is critically involved in reward-
based reinforcement learning,. However, it remains unclear how dopamine reward signals …

Neuron-type-specific signals for reward and punishment in the ventral tegmental area

JY Cohen, S Haesler, L Vong, BB Lowell, N Uchida - nature, 2012 - nature.com
Dopamine has a central role in motivation and reward. Dopaminergic neurons in the ventral
tegmental area (VTA) signal the discrepancy between expected and actual rewards (that is …

Rats and humans can optimally accumulate evidence for decision-making

BW Brunton, MM Botvinick, CD Brody - Science, 2013 - science.org
The gradual and noisy accumulation of evidence is a fundamental component of decision-
making, with noise playing a key role as the source of variability and errors. However, the …