miR‐203a—A multifaceted regulator modulating cancer hallmarks and therapy response
MicroRNAs (miRNAs) are a class of noncoding RNAs of about 19–25 nucleotides, which
serve as critical modulators of various cellular and biological processes by target gene …
serve as critical modulators of various cellular and biological processes by target gene …
Targeting IFN/STAT1 pathway as a promising strategy to overcome radioresistance
The interferon (IFN)-mediated activation of the Janus kinase (JAK)-signal transducer and
activator of transcription 1 (STAT1) signaling is crucial for cell sensitivity to ionizing radiation …
activator of transcription 1 (STAT1) signaling is crucial for cell sensitivity to ionizing radiation …
miR-124 and miR-203 synergistically inactivate EMT pathway via coregulation of ZEB2 in clear cell renal cell carcinoma (ccRCC)
J Chen, Y Zhong, L Li - Journal of Translational Medicine, 2020 - Springer
Background Clear cell renal cell carcinoma (ccRCC) is one of the most aggressive
urological malignancies. MicroRNAs (miRNAs) are post-transcriptional gene regulators in …
urological malignancies. MicroRNAs (miRNAs) are post-transcriptional gene regulators in …
MiR-30b attenuates neuropathic pain by regulating voltage-gated sodium channel Nav1. 3 in rats
S Su, J Shao, Q Zhao, X Ren, W Cai, L Li… - Frontiers in molecular …, 2017 - frontiersin.org
Nav1. 3 is a tetrodotoxin-sensitive isoform among voltage-gated sodium channels that are
closely associated with neuropathic pain. It can be up-regulated following nerve injury, but …
closely associated with neuropathic pain. It can be up-regulated following nerve injury, but …
A functional precision medicine pipeline combines comparative transcriptomics and tumor organoid modeling to identify bespoke treatment strategies for glioblastoma
MR Reed, AG Lyle, A De Loose, L Maddukuri… - Cells, 2021 - mdpi.com
Li Fraumeni syndrome (LFS) is a hereditary cancer predisposition syndrome caused by
germline mutations in TP53. TP53 is the most common mutated gene in human cancer …
germline mutations in TP53. TP53 is the most common mutated gene in human cancer …
[HTML][HTML] The critical role that STAT3 plays in glioma-initiating cells: STAT3 addiction in glioma
Abstract Glioma-Initiating Cells (GICs) are thought to be responsible for tumor initiation,
progression and recurrence in glioblastoma (GBM). In previous studies, we reported the …
progression and recurrence in glioblastoma (GBM). In previous studies, we reported the …
Chromatin remodeling factor BRG1 regulates stemness and chemosensitivity of glioma initiating cells
Glioblastoma multiforme (GBM) is a highly aggressive and malignant brain tumor that is
refractory to existing therapeutic regimens, which reflects the presence of stem-like cells …
refractory to existing therapeutic regimens, which reflects the presence of stem-like cells …
MiR-182-5p and its target HOXA9 in non-small cell lung cancer: a clinical and in-silico exploration with the combination of RT-qPCR, miRNA-seq and miRNA-chip
L Gao, S Yan, J Yang, J Kong, K Shi, F Ma… - BMC medical …, 2020 - Springer
Abstract Background MiR-182-5p, a cancer-related microRNA (miRNA), modulates
tumorigenesis and patient outcomes in various human malignances. This study interroted …
tumorigenesis and patient outcomes in various human malignances. This study interroted …
MicroRNA-1 suppresses glioblastoma in preclinical models by targeting fibronectin
Glioblastoma (GBM) is a deadly and incurable brain tumor. Although microRNAs (miRNAs)
play critical roles in regulating the cancer cell phenotype, the underlying mechanisms of how …
play critical roles in regulating the cancer cell phenotype, the underlying mechanisms of how …
How microRNAs affect the PD-L1 and its synthetic pathway in cancer
Programmed cell death-ligand 1 (PD-L1) is a glycoprotein that is expressed on the cell
surface of both hematopoietic and nonhematopoietic cells. PD-L1 play a role in the immune …
surface of both hematopoietic and nonhematopoietic cells. PD-L1 play a role in the immune …