Exposure to stress is an undeniable, but in most cases surmountable, part of life. However,
in certain individuals, exposure to severe or cumulative stressors can lead to an array of …

The high heterogeneity of psychiatric disorders leads to a lack of diagnostic precision.
Therefore, the search of biomarkers is a fundamental aspect in psychiatry to reach a more …

The human gut is a composite anaerobic environment with a large, diverse and dynamic
enteric microbiota, represented by more than 100 trillion microorganisms, including at least …

Cannabidiol (CBD), a major phytocannabinoid constituent of cannabis, is attracting growing
attention in medicine for its anxiolytic, antipsychotic, antiemetic and anti-inflammatory …

Cannabis has been used for hundreds of years, with its ability to dampen feelings of anxiety
often reported as a primary reason for use. Only recently has the specific role cannabinoids …

Evidence for the involvement of the endocannabinoid system (ECS) in anxiety and fear has
been accumulated, providing leads for novel therapeutic approaches. In anxiety, a …

Anandamide is a lipid mediator that acts as an endogenous ligand of CB1 receptors. These
receptors are also the primary molecular target responsible for the pharmacological effects …

Cannabis has long been known to produce cognitive and emotional effects. Research has
shown that cannabinoid drugs produce these effects by driving the brain's endogenous …

BACKGROUND: Fatty acid amide hydrolase (FAAH) is a key enzyme in regulating
endocannabinoid (eCB) signaling. A common single nucleotide polymorphism (C385A) in …

Increases in mesolimbic dopamine transmission are observed when animals are treated
with all known drugs of abuse, including cannabis, and to conditioned stimuli predicting their …