Tissue clearing to examine tumour complexity in three dimensions
The visualization of whole organs and organisms through tissue clearing and fluorescence
volumetric imaging has revolutionized the way we look at biological samples. Its application …
volumetric imaging has revolutionized the way we look at biological samples. Its application …
Biomedical applications of tissue clearing and three-dimensional imaging in health and disease
Summary Three-dimensional (3D) optical imaging techniques can expand our knowledge
about physiological and pathological processes that cannot be fully understood with 2D …
about physiological and pathological processes that cannot be fully understood with 2D …
Intraclonal plasticity in mammary tumors revealed through large-scale single-cell resolution 3D imaging
AC Rios, BD Capaldo, F Vaillant, B Pal, R van Ineveld… - Cancer cell, 2019 - cell.com
Breast tumors are inherently heterogeneous, but the evolving cellular organization through
neoplastic progression is poorly understood. Here we report a rapid, large-scale single-cell …
neoplastic progression is poorly understood. Here we report a rapid, large-scale single-cell …
Hydrogel-tissue chemistry: principles and applications
Over the past five years, a rapidly develo** experimental approach has enabled high-
resolution and high-content information retrieval from intact multicellular animal (metazoan) …
resolution and high-content information retrieval from intact multicellular animal (metazoan) …
CUBIC pathology: three-dimensional imaging for pathological diagnosis
S Nojima, EA Susaki, K Yoshida, H Takemoto… - Scientific reports, 2017 - nature.com
The examination of hematoxylin and eosin (H&E)-stained tissues on glass slides by
conventional light microscopy is the foundation for histopathological diagnosis. However …
conventional light microscopy is the foundation for histopathological diagnosis. However …
CSF1R-dependent macrophages control postnatal somatic growth and organ maturation
S Keshvari, M Caruso, N Teakle, L Batoon… - PLoS …, 2021 - journals.plos.org
Homozygous mutation of the Csf1r locus (Csf1rko) in mice, rats and humans leads to
multiple postnatal developmental abnormalities. To enable analysis of the mechanisms …
multiple postnatal developmental abnormalities. To enable analysis of the mechanisms …
Multiscale imaging of basal cell dynamics in the functionally mature mammary gland
AJ Stevenson, G Vanwalleghem… - Proceedings of the …, 2020 - National Acad Sciences
The mammary epithelium is indispensable for the continued survival of more than 5,000
mammalian species. For some, the volume of milk ejected in a single day exceeds their …
mammalian species. For some, the volume of milk ejected in a single day exceeds their …
Advances in ex situ tissue optical clearing
Examination of whole organs with subcellular resolution in health, disease, and during
development is necessary to decipher their biological complexity. However, until recently …
development is necessary to decipher their biological complexity. However, until recently …
Mammary stem cells: premise, properties, and perspectives
Adult mammary stem cells (MaSCs) drive postnatal organogenesis and remodeling in the
mammary gland, and their longevity and potential have important implications for breast …
mammary gland, and their longevity and potential have important implications for breast …
Imaging the invisible—Bioorthogonal Raman probes for imaging of cells and tissues
G Azemtsop Matanfack, J Rüger… - Journal of …, 2020 - Wiley Online Library
A revolutionary avenue for vibrational imaging with super‐multiplexing capability can be
seen in the recent development of Raman‐active bioortogonal tags or labels. These tags …
seen in the recent development of Raman‐active bioortogonal tags or labels. These tags …