[HTML][HTML] Angiotensin-converting enzyme 2 (ACE2): SARS-CoV-2 receptor and RAS modulator

J Bian, Z Li - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Abstract The coronavirus disease 2019 (COVID-19) outbreak is caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). Angiotensin-converting enzyme 2 …

Molecular biology of the SARs‐CoV‐2 spike protein: A review of current knowledge

C Zhu, G He, Q Yin, L Zeng, X Ye… - Journal of medical …, 2021 - Wiley Online Library
The global coronavirus disease 2019 (COVID‐19) pandemic, caused by the severe acute
respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has led to an unprecedented worldwide …

Targeting the renin–angiotensin–aldosterone system to prevent hypertension and kidney disease of developmental origins

CN Hsu, YL Tain - International Journal of Molecular Sciences, 2021 - mdpi.com
The renin-angiotensin-aldosterone system (RAAS) is implicated in hypertension and kidney
disease. The develo** kidney can be programmed by various early-life insults by so …

Cardiovascular diseases of developmental origins: Preventive aspects of gut microbiota-targeted therapy

CN Hsu, CY Hou, WH Hsu, YL Tain - Nutrients, 2021 - mdpi.com
Cardiovascular diseases (CVDs) can originate from early life. Accumulating evidence
suggests that gut microbiota in early life is linked to CVDs in later life. Gut microbiota …

Cardiac autonomic neuropathy: a progressive consequence of chronic low-grade inflammation in type 2 diabetes and related metabolic disorders

NMZ Bakkar, HS Dwaib, S Fares, AH Eid… - International journal of …, 2020 - mdpi.com
Cardiac autonomic neuropathy (CAN) is one of the earliest complications of type 2 diabetes
(T2D), presenting a silent cause of cardiovascular morbidity and mortality. Recent research …

Maternal resveratrol therapy protected adult rat offspring against hypertension programmed by combined exposures to asymmetric dimethylarginine and …

CN Hsu, CY Hou, GP Chang-Chien, S Lin… - The Journal of nutritional …, 2021 - Elsevier
Resveratrol, a phytochemical, has shown antioxidant properties and potential benefits in
hypertension. Asymmetric dimethylarginine (ADMA)-related nitric oxide deficiency and gut …

Premises among SARS-CoV-2, dysbiosis and diarrhea: Walking through the ACE2/mTOR/autophagy route

AP de Oliveira, ALF Lopes, G Pacheco, IRSG Nolêto… - Medical hypotheses, 2020 - Elsevier
Recently, a new coronavirus (SARS-CoV-2) was discovered in China. Due to its high level of
contagion, it has already reached most countries, quickly becoming a pandemic. Although …

ACE2 in the gut: the center of the 2019-nCoV infected pathology

Y Guo, B Wang, H Gao, L Gao, R Hua… - Frontiers in Molecular …, 2021 - frontiersin.org
The 2019-nCoV is a rapidly contagious pneumonia caused by the recently discovered
coronavirus. Although generally the most noticeable symptoms are concentrated in the …

Gut microbiota: Implications in pathogenesis and therapy to cardiovascular disease

L Lin, S **ang, Y Chen, Y Liu… - Experimental and …, 2024 - spandidos-publications.com
The gut microbiota refers to the diverse bacterial community residing in the gastrointestinal
tract. Recent data indicate a strong correlation between alterations in the gut microbiota …

The emerging role of metabolism in brain-heart axis: new challenge for the therapy and prevention of Alzheimer disease. May thioredoxin interacting protein (TXNIP) …

L Perrone, M Valente - Biomolecules, 2021 - mdpi.com
Alzheimer disease (AD) is the most frequent cause of dementia and up to now there is not
an effective therapy to cure AD. In addition, AD onset occurs decades before the diagnosis …