The amyloid cascade hypothesis: an updated critical review
Results from recent clinical trials of antibodies that target amyloid-β (Aβ) for Alzheimer's
disease have created excitement and have been heralded as corroboration of the amyloid …
disease have created excitement and have been heralded as corroboration of the amyloid …
Development of multifunctional molecules as potential therapeutic candidates for Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis in the …
Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
Metal ions in Alzheimer's disease: a key role or not?
Y Liu, M Nguyen, A Robert… - Accounts of chemical …, 2019 - ACS Publications
Conspectus Despite tremendous research efforts in universities and pharmaceutical
companies, effective drugs are still lacking for the treatment of Alzheimer's disease (AD). The …
companies, effective drugs are still lacking for the treatment of Alzheimer's disease (AD). The …
Metal Binding of Alzheimer's Amyloid-β and Its Effect on Peptide Self-Assembly
A Abelein - Accounts of Chemical Research, 2023 - ACS Publications
Conspectus Metal ions have been identified as key factors modulating the aggregation of
amyloid-β peptide (Aβ) implicated in Alzheimer's disease (AD). The presence of elevated …
amyloid-β peptide (Aβ) implicated in Alzheimer's disease (AD). The presence of elevated …
Naturally occurring antioxidant therapy in Alzheimer's disease
AE Collins, TM Saleh, BE Kalisch - Antioxidants, 2022 - mdpi.com
It is estimated that the prevalence rate of Alzheimer's disease (AD) will double by the year
2040. Although currently available treatments help with symptom management, they do not …
2040. Although currently available treatments help with symptom management, they do not …
Biomedical applications of copper ionophores
V Oliveri - Coordination Chemistry Reviews, 2020 - Elsevier
Copper dyshomeostasis is associated with a plethora of diseases, supporting the possibility
of applying copper ionophores to regenerate the metal homeostasis and treat copper …
of applying copper ionophores to regenerate the metal homeostasis and treat copper …
Polyphenols as potential metal chelation compounds against Alzheimer's disease
Alzheimer's disease (AD) is the most common neurodegenerative disease affecting more
than 50 million people worldwide. The pathology of this multifactorial disease is primarily …
than 50 million people worldwide. The pathology of this multifactorial disease is primarily …
Molecular structure of Cu (II)-bound amyloid-β monomer implicated in inhibition of peptide self-assembly in Alzheimer's disease
Metal ions, such as copper and zinc ions, have been shown to strongly modulate the self-
assembly of the amyloid-β (Aβ) peptide into insoluble fibrils, and elevated concentrations of …
assembly of the amyloid-β (Aβ) peptide into insoluble fibrils, and elevated concentrations of …
Cu and Zn coordination to amyloid peptides: From fascinating chemistry to debated pathological relevance
E Atrián-Blasco, P Gonzalez, A Santoro, B Alies… - Coordination chemistry …, 2018 - Elsevier
Several diseases share misfolding of different peptides and proteins as a key feature for
their development. This is the case of important neurodegenerative diseases such as …
their development. This is the case of important neurodegenerative diseases such as …
Ag nanostructures as the surface plasmon resonance (SPR)˗ based sensors: a mechanistic study with an emphasis on heavy metallic ions detection
The ever increasing release of wastes and pollutants due to rapid industrialization perilously
impacts the environment and human lives. The toxic chemicals are routinely released into …
impacts the environment and human lives. The toxic chemicals are routinely released into …