Colorectal cancer (CRC) is the third most common cancer and the second leading cause of
cancer-related death worldwide. Countless CRC patients undergo disease progression. As …

Reactive oxygen species (ROS) are by‐products of normal cell activity. They are produced
in many cellular compartments and play a major role in signaling pathways. Overproduction …

The epithelial-mesenchymal transition (EMT) represents a biological program during which
epithelial cells lose their cell identity and acquire a mesenchymal phenotype. EMT is …

Cancer reprogramming is an important facilitator of cancer development and survival, with
tumor cells exhibiting a preference for aerobic glycolysis beyond oxidative phosphorylation …

Glucose metabolism is indispensable for cell growth and survival. Hexokinases play pivotal
roles in glucose metabolism through canonical functions of hexokinases as well as in …

Background Cancer cell is generally characterized by enhanced glycolysis. Inflammasome
activation is interaction with glycolysis. The concentration of lipopolysaccharide (LPS), a …

Metabolic rearrangement is a marker of cancer that has been widely studied in recent years.
One of the major metabolic characteristics of tumor cells is the high levels of glycolysis, even …

Abstract CircZBTB44 (hsa_circ_0002484) has been identified to be upregulated in renal cell
carcinoma (RCC) tissues, while its role and contribution in RCC remain elusive. We …

Background Cell metabolism plays a pivotal role in tumor progression, and targeting cancer
metabolism might effectively kill cancer cells. We aimed to investigate the role of …

Mammalian target of rapamycin (mTOR) serves an important role in regulating various
biological processes, including cell proliferation, metabolism, apoptosis and autophagy …