Targeting cancer with mRNA–lipid nanoparticles: key considerations and future prospects
E Kon, N Ad-El, I Hazan-Halevy… - Nature reviews clinical …, 2023 - nature.com
Harnessing mRNA–lipid nanoparticles (LNPs) to treat patients with cancer has been an
ongoing research area that started before these versatile nanoparticles were successfully …
ongoing research area that started before these versatile nanoparticles were successfully …
Strategies to improve the EPR effect: A mechanistic perspective and clinical translation
Many efforts have been made to achieve targeted delivery of anticancer drugs to enhance
their efficacy and to reduce their adverse effects. These efforts include the development of …
their efficacy and to reduce their adverse effects. These efforts include the development of …
Engineered nanomedicines with enhanced tumor penetration
Nanomedicine has been extensively explored to enhance the efficacy of chemotherapy with
modest therapeutic efficacy in the clinic, owing to various factors. A primary factor is …
modest therapeutic efficacy in the clinic, owing to various factors. A primary factor is …
Self‐assembled peptide‐based nanomaterials for biomedical imaging and therapy
GB Qi, YJ Gao, L Wang, H Wang - Advanced materials, 2018 - Wiley Online Library
Peptide‐based materials are one of the most important biomaterials, with diverse structures
and functionalities. Over the past few decades, a self‐assembly strategy is introduced to …
and functionalities. Over the past few decades, a self‐assembly strategy is introduced to …
[HTML][HTML] Ferroptosis-induced anticancer effect of resveratrol with a biomimetic nano-delivery system in colorectal cancer treatment
Z Zhang, Y Ji, N Hu, Q Yu, X Zhang, J Li, F Wu… - Asian Journal of …, 2022 - Elsevier
Ferroptosis is a novel form of programmed cell death impelled by iron-dependent lipid
peroxidation, which may be a potential strategy for cancer therapy. Here we demonstrated …
peroxidation, which may be a potential strategy for cancer therapy. Here we demonstrated …
Tumor penetrating peptides for improved drug delivery
E Ruoslahti - Advanced drug delivery reviews, 2017 - Elsevier
In vivo screening of phage libraries in tumor-bearing mice has been used to identify
peptides that direct phage homing to a tumor. The power of in vivo phage screening is …
peptides that direct phage homing to a tumor. The power of in vivo phage screening is …
Lipid based nanoparticles as a novel treatment modality for hepatocellular carcinoma: a comprehensive review on targeting and recent advances
Liver cancer is considered one of the deadliest diseases with one of the highest disease
burdens worldwide. Among the different types of liver cancer, hepatocellular carcinoma is …
burdens worldwide. Among the different types of liver cancer, hepatocellular carcinoma is …
Current development of siRNA bioconjugates: from research to the clinic
IV Chernikov, VV Vlassov… - Frontiers in …, 2019 - frontiersin.org
Small interfering RNAs (siRNAs) acting via RNA interference mechanisms are able to
recognize a homologous mRNA sequence in the cell and induce its degradation. The main …
recognize a homologous mRNA sequence in the cell and induce its degradation. The main …
Membrane active peptides and their biophysical characterization
In the last 20 years, an increasing number of studies have been reported on membrane
active peptides. These peptides exert their biological activity by interacting with the cell …
active peptides. These peptides exert their biological activity by interacting with the cell …
An update on actively targeted liposomes in advanced drug delivery to glioma
High-grade glioma is one of the most aggressive types of cancer with a low survival rate
ranging from 12 to 15 months after the first diagnosis. Though being the most common …
ranging from 12 to 15 months after the first diagnosis. Though being the most common …