Organelles compartmentalize eukaryotic cells, enhancing their ability to respond to
environmental and developmental changes. One way in which organelles communicate and …

Biomembranes are complex materials composed of lipids and proteins that
compartmentalize biochemistry. They are actively remodeled in response to physical and …

Septins belong to a family of proteins that is highly conserved in eukaryotes and is
increasingly recognized as a novel component of the cytoskeleton. All septins are GTP …

Eukaryotic cells must contend with a continuous stream of misfolded proteins that
compromise the cellular protein homeostasis balance and jeopardize cell viability. An …

In dividing cells, nuclear pore complexes (NPCs) disassemble during mitosis and
reassemble into the newly forming nuclei. However, the fate of nuclear pores in postmitotic …

The past decade has seen fundamental advances in our understanding of the ageing
process and raised optimism that interventions to slow ageing may be on the horizon …

Cell division in eukaryotes requires extensive architectural changes of the nuclear envelope
(NE) to ensure that segregated DNA is finally enclosed in a single cell nucleus in each …

Changes to the chromatin structure accompany aging, but the molecular mechanisms
underlying aging and the accompanying changes to the chromatin are unclear. Here, we …

Cell division is commonly thought to involve the equal distribution of cellular components
into the two daughter cells. During many cell divisions, however, proteins, membrane …

Nuclear pore complexes (NPCs) are the only transport channels that cross the nuclear
envelope. Constructed from~ 500–1000 nucleoporin proteins each, they are among the …