Parenchymal lung disease is the fourth leading cause of death in the United States; among
the top causes, it continues on the rise. Telomeres and telomerase have historically been …

A current hypothesis gaining prominence proposes that activation of the enzyme telomerase
is necessary for cells to become immortal, or capable of proliferating indefinitely. The theory …

We describe a map of 1.42 million single nucleotide polymorphisms (SNPs) distributed
throughout the human genome, providing an average density on available sequence of one …

Loss of telomeric DNA during cell proliferation may play a role in ageing and cancer. Since
telomeres permit complete replication of eukaryotic chromosomes and protect their ends …

Scientific discoveries are each individual and occur by their own unique path. However,
there are key ingredients that set the stage for them. Many of these ingredients were …

We have developed a method for constructing genomic libraries enriched for telomeric DNA
sequences, enabling the isolation of telomeres from higher eukaryotic organisms with large …

A systematic search of the nonrecombining region of the human Y chromosome (NRY)
identified 12 novel genes or families, 10 with full-length complementary DNA sequences. All …

We report the construction of a linkage map of the human genome, based on the pattern of
inheritance of 403 polymorphic loci, including 393 RFLPs, in a panel of DNAs from 21 three …

The presence or absence of the Y chromosome determines whether a mammalian embryo
develops as a male or female. In humans, genetic deletion analysis of" sex-reversed" …

A major challenge for human genetics is to identify new causes of mental retardation, which,
although present in about 3% of individuals, is unexplained in more than half of all cases …