There is extensive evidence that effective screening for major chromosomal abnormalities
can be provided in the first trimester of pregnancy. Prospective studies in a total of 200,868 …

Background Down's syndrome occurs when a person has three, rather than two copies of
chromosome 21; or the specific area of chromosome 21 implicated in causing Down's …

Chromosomal abnormalities are major causes of perinatal death and childhood handicap.
Consequently, the detection of chromosomal disorders constitutes the most frequent …

Objective To evaluate the performance of a one‐stop clinic for assessment of risk (OSCAR)
for trisomy 21 by a combination of maternal age, fetal nuchal translucency (NT) thickness …

Screening for Down syndrome is an important part of routine antenatal care. The most
common screening method in the United States involves the assessment of a combination of …

Objective To evaluate the association between abnormal ductus venosus (DV) at 11–14
weeks' gestation and chromosomal abnormalities, structural defects and fetal outcome …

Objective To determine the accuracy and practicality of fetal echocardiography in the
identification of structural and functional cardiac abnormalities prior to 16 weeks' gestation in …

Objective: To evaluate which Down syndrome screening strategy is the most cost-effective.
Methods: Using decision-analysis modeling, we compared the cost-effectiveness of 9 …

Objective To examine the detection rate of chromosomal abnormalities using a combination
of nuchal translucency (NT) and maternal age in a United States population. Methods A total …

Increased nuchal translucency is the strongest single marker for chromosomal abnormality.
Consequently, it is currently becoming established as the foundation of most early screening …