Arginine metabolism has been a key catabolic and anabolic process throughout the
evolution of the immune response. Accruing evidence indicates that arginine-catabolizing …

Arginine methylation is now coming out of the shadows of protein phosphorylation and
entering the mainstream, largely due to the identification of the family of enzymes that lay …

Helper T cells coordinate immune responses through the production of cytokines. Th2 cells
express the closely linked Il4, Il13, and Il5 cytokine genes, whereas these same genes are …

Proteins with motifs rich in arginines and glycines were discovered decades ago and are
functionally involved in a staggering range of essential processes in the cell. Versatile …

Stress granules (SGs) are cytoplasmic condensates of stalled messenger ribonucleoprotein
complexes (mRNPs) that form when eukaryotic cells encounter environmental stress. RNA …

Many key cellular processes can be regulated by the seemingly simple addition of one, or
two, methyl groups to arginine residues by the nine known mammalian protein arginine …

The Ca2+ dependent transcription factor family known as nuclear factor of activated T cells
(NFAT) has been shown to be important in T-cell immune responses. Because NFAT …

The Tudor domain is an∼ 60-amino acid structure motif in search of a function. Herein we
show that the Tudor domains of the spinal muscular atrophy gene product SMN, the splicing …

During the last few years, new members of the growing family of protein arginine
methyltransferases (PRMTs) have been identified and the role of arginine methylation in …

In order for an immune response to be successful, it must be of the appropriate type and
magnitude. Intracellular residing pathogens require a cell‐mediated immune response …