Cancer organoids 2.0: modelling the complexity of the tumour immune microenvironment
R Polak, ET Zhang, CJ Kuo - Nature Reviews Cancer, 2024 - nature.com
The development of neoplasia involves a complex and continuous interplay between
malignantly transformed cells and the tumour microenvironment (TME). Cancer …
malignantly transformed cells and the tumour microenvironment (TME). Cancer …
The hallmarks of cancer immune evasion
According to the widely accepted" three Es" model, the host immune system eliminates
malignant cell precursors and contains microscopic neoplasms in a dynamic equilibrium …
malignant cell precursors and contains microscopic neoplasms in a dynamic equilibrium …
The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity
Immune checkpoint blockade is effective for some patients with cancer, but most are
refractory to current immunotherapies and new approaches are needed to overcome …
refractory to current immunotherapies and new approaches are needed to overcome …
Cancer cells resistant to immune checkpoint blockade acquire interferon-associated epigenetic memory to sustain T cell dysfunction
Prolonged interferon (IFN) signaling in cancer cells can promote resistance to immune
checkpoint blockade (ICB). How cancer cells retain effects of prolonged IFN stimulation to …
checkpoint blockade (ICB). How cancer cells retain effects of prolonged IFN stimulation to …
LAG-3 sustains TOX expression and regulates the CD94/NKG2-Qa-1b axis to govern exhausted CD8 T cell NK receptor expression and cytotoxicity
Summary Exhausted CD8 T (T ex) cells in chronic viral infection and cancer have sustained
co-expression of inhibitory receptors (IRs). T ex cells can be reinvigorated by blocking IRs …
co-expression of inhibitory receptors (IRs). T ex cells can be reinvigorated by blocking IRs …
Glycosphingolipid synthesis mediates immune evasion in KRAS-driven cancer
Cancer cells frequently alter their lipids to grow and adapt to their environment,–. Despite
the critical functions of lipid metabolism in membrane physiology, signalling and energy …
the critical functions of lipid metabolism in membrane physiology, signalling and energy …
Defining and using immune archetypes to classify and treat cancer
Tumours are surrounded by a host immune system that can suppress or promote tumour
growth. The tumour microenvironment (TME) has often been framed as a singular entity …
growth. The tumour microenvironment (TME) has often been framed as a singular entity …
Sequential immunotherapy and targeted therapy for metastatic BRAF V600 mutated melanoma: 4-year survival and biomarkers evaluation from the phase II …
No prospective data were available prior to 2021 to inform selection between combination
BRAF and MEK inhibition versus dual blockade of programmed cell death protein-1 (PD-1) …
BRAF and MEK inhibition versus dual blockade of programmed cell death protein-1 (PD-1) …
Cancer cell-intrinsic mechanisms driving acquired immune tolerance
Immune evasion is a hallmark of cancer, enabling tumors to survive contact with the host
immune system and evade the cycle of immune recognition and destruction. Here, we …
immune system and evade the cycle of immune recognition and destruction. Here, we …
CRISPR screens for functional interrogation of immunity
CRISPR-based technologies represent a major breakthrough in biomedical science as they
offer a powerful platform for unbiased screening and functional genomics in various fields …
offer a powerful platform for unbiased screening and functional genomics in various fields …