Fatty acid biosynthesis, the first stage in membrane lipid biogenesis, is catalyzed in most
bacteria by a series of small, soluble proteins that are each encoded by a discrete gene (Fig …

The modern age of drug discovery, which had been slowly gathering momentum during the
early part of the twentieth century, exploded into life in the 1940s with the isolation of …

Isoniazid (INH), a frontline antitubercular drug, inhibits InhA, the enoyl reductase from
Mycobacterium tuberculosis, by forming a covalent adduct with the NAD cofactor. Here, we …

In view of the worldwide spread of multidrug resistance of Mycobacterium tuberculosis, there
is an urgent need to discover antituberculosis agent with novel structures. InhA, the enoyl …

Structural and genetic studies indicate that the antibacterial compound triclosan, an additive
in many personal care products, is an inhibitor of EnvM, the enoyl reductase from …

InhA, the enoyl-ACP reductase in Mycobacterium tuberculosis is an attractive target for the
development of novel drugs against tuberculosis, a disease that kills more than two million …

Antibiotic resistance is a serious public health concern, and new drugs are needed to
ensure effective treatment of many bacterial infections. Bacterial type II fatty acid synthesis …

N ɛ-Acetylation of lysine residues represents a pivotal post-translational modification used
by both eukaryotes and prokaryotes to modulate diverse biological processes …

The human malaria parasite Plasmodium falciparum synthesizes fatty acids using a type II
pathway that is absent in humans. The final step in fatty acid elongation is catalyzed by …

The relative global 2 H-content of natural plant products is correlated to that of the primary
hydrogen source, ie water, to the site of their biosynthesis (C 3-, C 4-and CAM-plants; …