Novel noninvasive approaches to the treatment of obesity: from pharmacotherapy to gene therapy

AM Angelidi, MJ Belanger, A Kokkinos… - Endocrine …, 2022 - academic.oup.com
Recent insights into the pathophysiologic underlying mechanisms of obesity have led to the
discovery of several promising drug targets and novel therapeutic strategies to address the …

International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB1 and CB2

RG Pertwee, AC Howlett, ME Abood… - Pharmacological …, 2010 - Elsevier
There are at least two types of cannabinoid receptors (CB 1 and CB 2). Ligands activating
these G protein-coupled receptors (GPCRs) include the phytocannabinoid Δ 9 …

Cannabinoid type 2 receptors mediate a cell type-specific plasticity in the hippocampus

AV Stempel, A Stumpf, HY Zhang, T Özdoğan… - Neuron, 2016 - cell.com
Endocannabinoids (eCBs) exert major control over neuronal activity by activating
cannabinoid receptors (CBRs). The functionality of the eCB system is primarily ascribed to …

[HTML][HTML] The effects of cannabidiol, a non-intoxicating compound of cannabis, on the cardiovascular system in health and disease

A Kicman, M Toczek - International journal of molecular sciences, 2020 - mdpi.com
Cannabidiol (CBD) is a non-intoxicating and generally well-tolerated constituent of cannabis
which exhibits potential beneficial properties in a wide range of diseases, including …

The essential medicinal chemistry of cannabidiol (CBD)

KM Nelson, J Bisson, G Singh, JG Graham… - Journal of medicinal …, 2020 - ACS Publications
This Perspective of the published essential medicinal chemistry of cannabidiol (CBD)
provides evidence that the popularization of CBD-fortified or CBD-labeled health products …

Cannabinoid and cannabinoid‐like receptors in microglia, astrocytes, and astrocytomas

N Stella - Glia, 2010 - Wiley Online Library
CB1 and CB2 receptors are activated by a plethora of cannabinoid compounds, be they
endogenously‐produced, plant‐derived or synthetic. These receptors are expressed by …

The endocannabinoid system and pain

J Guindon, AG Hohmann - CNS & Neurological Disorders-Drug …, 2009 - ingentaconnect.com
The therapeutic potential of cannabinoids has been the topic of extensive investigation
following the discovery of cannabinoid receptors and their endogenous ligands …

An overview on medicinal chemistry of synthetic and natural derivatives of cannabidiol

P Morales, PH Reggio, N Jagerovic - Frontiers in pharmacology, 2017 - frontiersin.org
Cannabidiol (CBD) has been traditionally used in Cannabis-based preparation, however
historically, it has received far less interest as a single drug than the other components of …

An overview on synthetic and biological activities of cannabidiol (CBD) and its derivatives

X Wang, H Zhang, Y Liu, Y Xu, B Yang, H Li… - Bioorganic Chemistry, 2023 - Elsevier
Cannabidiol is a class of non-psychoactive plant cannabinoids derived from cannabis
plants. Currently, Epidiolex (Cannabidiol) has been approved by the FDA for the treatment of …

Beyond THC and endocannabinoids

P Pacher, NM Kogan… - Annual review of …, 2020 - annualreviews.org
Research in the cannabinoid field, namely on phytocannabinoids, the endogenous
cannabinoids anandamide and 2-arachidonoyl glycerol and their metabolizing and synthetic …