Virus-specific CD8+ T cells that differentiate in the context of resolved versus persisting
infections exhibit divergent phenotypic and functional characteristics, which suggests that …

Considerable advances have been made in recent years in understanding the generation
and function of memory T cells. Memory T cells are typically parsed into discreet subsets …

Background Monkeypox virus has recently infected more than 88 000 people, raising
concerns about our preparedness against this emerging viral pathogen. Licensed and …

Aging leads to numerous changes that affect all physiological systems of the body including
the immune system, causing greater susceptibility to infectious disease and contributing to …

Human cytomegalovirus (HCMV) establishes a latent infection that generally remains
asymptomatic in immune-competent hosts for decades but can cause serious illness in …

The significantly higher mortality rates seen in the elderly compared with young children
during the coronavirus disease 2019 (Covid‐19) pandemic is likely to be driven in part by an …

A protective vaccine against hepatitis C virus (HCV) remains an unmet clinical need. HCV
infects millions of people worldwide and is a leading cause of liver cirrhosis and …

Aging is associated with a dysregulation of the immune response, loosely termed
“immunosenescence.” Each part of the immune system is influenced to some extent by the …

The impact of intrinsic aging upon human peripheral blood T cell subsets remains
incompletely quantified and understood. This impact must be distinguished from the …

Following primary infection, human cytomegalovirus (HCMV) establishes lifelong latency
and periodically reactivates without causing symptoms in healthy individuals. In the absence …