Advantages and limitations of current network inference methods

R De Smet, K Marchal - Nature Reviews Microbiology, 2010 - nature.com
Network inference, which is the reconstruction of biological networks from high-throughput
data, can provide valuable information about the regulation of gene expression in cells …

Demystifying the secret mission of enhancers: linking distal regulatory elements to target genes

L Yao, BP Berman, PJ Farnham - Critical reviews in biochemistry …, 2015 - Taylor & Francis
Enhancers are short regulatory sequences bound by sequence-specific transcription factors
and play a major role in the spatiotemporal specificity of gene expression patterns in …

Target analysis by integration of transcriptome and ChIP-seq data with BETA

S Wang, H Sun, J Ma, C Zang, C Wang, J Wang… - Nature protocols, 2013 - nature.com
The combination of ChIP-seq and transcriptome analysis is a compelling approach to
unravel the regulation of gene expression. Several recently published methods combine …

[PDF][PDF] Computationally efficient convolved multiple output Gaussian processes

MA Alvarez, ND Lawrence - The Journal of Machine Learning Research, 2011 - jmlr.org
Recently there has been an increasing interest in regression methods that deal with multiple
outputs. This has been motivated partly by frameworks like multitask learning, multisensor …

Inferring gene regulatory networks from gene expression data by path consistency algorithm based on conditional mutual information

X Zhang, XM Zhao, K He, L Lu, Y Cao, J Liu… - …, 2012 - academic.oup.com
Motivation: Reconstruction of gene regulatory networks (GRNs), which explicitly represent
the causality of developmental or regulatory process, is of utmost interest and has become a …

A gene regulatory network for root epidermis cell differentiation in Arabidopsis

A Bruex, RM Kainkaryam, Y Wieckowski, YH Kang… - PLoS …, 2012 - journals.plos.org
The root epidermis of Arabidopsis provides an exceptional model for studying the molecular
basis of cell fate and differentiation. To obtain a systems-level view of root epidermal cell …

Measuring absolute RNA copy numbers at high temporal resolution reveals transcriptome kinetics in development

NDL Owens, IL Blitz, MA Lane, I Patrushev, JD Overton… - Cell reports, 2016 - cell.com
Transcript regulation is essential for cell function, and misregulation can lead to disease.
Despite technologies to survey the transcriptome, we lack a comprehensive understanding …

Inference of gene regulatory network based on local Bayesian networks

F Liu, SW Zhang, WF Guo, ZG Wei… - PLoS computational …, 2016 - journals.plos.org
The inference of gene regulatory networks (GRNs) from expression data can mine the direct
regulations among genes and gain deep insights into biological processes at a network …

Reconstructing gene regulatory dynamics from high-dimensional single-cell snapshot data

A Ocone, L Haghverdi, NS Mueller, FJ Theis - Bioinformatics, 2015 - academic.oup.com
Motivation: High-dimensional single-cell snapshot data are becoming widespread in the
systems biology community, as a mean to understand biological processes at the cellular …

Inferring gene regulatory networks using the improved Markov blanket discovery algorithm

W Liu, Y Jiang, L Peng, X Sun, W Gan, Q Zhao… - Interdisciplinary …, 2022 - Springer
Inferring gene regulatory networks (GRNs) from microarray data can help us understand the
mechanisms of life and eventually develop effective therapies. Currently, many …