Bruce McEwen's discovery of receptors for corticosterone in the rat hippocampus introduced
higher brain circuits in the neuroendocrinology of stress. Subsequently, these receptors …

Adrenal glucocorticoid hormones are crucial for maintenance of homeostasis and
adaptation to stress. They act via the mineralocorticoid receptors (MRs) and glucocorticoid …

Aldosterone regulates sodium homeostasis by activating the mineralocorticoid receptor
(MR), a member of the nuclear receptor superfamily. Hyperaldosteronism leads …

During the past decades, the mineralocorticoid receptor (MR) has evolved from a much‐
overlooked member of the steroid hormone receptor family to an important player, not only in …

Brain-derived neurotrophic factor (BDNF) is involved in many functions such as neuronal
growth, survival, synaptic plasticity and memorization. Altered expression levels are …

Corticosteroid hormones act in the brain to support adaptation to stress via binding to
mineralocorticoid and glucocorticoid receptors (MR and GR). These receptors act in large …

High-throughput sequencing technologies have allowed many gene locus–level molecular
biology assays to become genome-wide profiling methods. DNA-cleaving enzymes such as …

Endothelial cells play crucial roles in physiology and are increasingly recognized as
therapeutic targets in cardiovascular disease. Here, we analyzed the regulatory landscape …

In the limbic brain, mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs)
both function as receptors for the naturally occurring glucocorticoids (corticosterone/cortisol) …

Aldosterone exerts profound effects on renal and cardiovascular physiology. In the kidney,
aldosterone acts to preserve electrolyte and acid-base balance in response to changes in …