Macrophages in immunoregulation and therapeutics

S Chen, AFUH Saeed, Q Liu, Q Jiang, H Xu… - … and Targeted Therapy, 2023 - nature.com
Macrophages exist in various tissues, several body cavities, and around mucosal surfaces
and are a vital part of the innate immune system for host defense against many pathogens …

The signal pathways and treatment of cytokine storm in COVID-19

L Yang, X **e, Z Tu, J Fu, D Xu, Y Zhou - Signal transduction and …, 2021 - nature.com
Abstract The Coronavirus Disease 2019 (COVID-19) pandemic has become a global crisis
and is more devastating than any other previous infectious disease. It has affected a …

Network pharmacology prediction and molecular docking-based strategy to explore the potential mechanism of Huanglian Jiedu Decoction against sepsis

X Li, S Wei, S Niu, X Ma, H Li, M **g, Y Zhao - Computers in biology and …, 2022 - Elsevier
Abstract Background Huanglian Jiedu Decoction (HLJDD) is a classical herbal formula with
potential efficacy in the treatment of sepsis. However, the main components and potential …

Exploring the next generation of antibody–drug conjugates

K Tsuchikama, Y Anami, SYY Ha… - Nature Reviews Clinical …, 2024 - nature.com
Antibody–drug conjugates (ADCs) are a promising cancer treatment modality that enables
the selective delivery of highly cytotoxic payloads to tumours. However, realizing the full …

Innate receptor activation patterns involving TLR and NLR synergisms in COVID-19, ALI/ARDS and sepsis cytokine storms: a review and model making novel …

R Root-Bernstein - International journal of molecular sciences, 2021 - mdpi.com
Severe COVID-19 is characterized by a “cytokine storm”, the mechanism of which is not yet
understood. I propose that cytokine storms result from synergistic interactions among Toll …

Inflammation balance in skeletal muscle damage and repair

H Tu, YL Li - Frontiers in immunology, 2023 - frontiersin.org
Responding to tissue injury, skeletal muscles undergo the tissue destruction and
reconstruction accompanied with inflammation. The immune system recognizes the …

Pathogenesis and treatment of cytokine storm induced by infectious diseases

XD Tang, TT Ji, JR Dong, H Feng, FQ Chen… - International journal of …, 2021 - mdpi.com
Cytokine storm is a phenomenon characterized by strong elevated circulating cytokines that
most often occur after an overreactive immune system is activated by an acute systemic …

The trinity of cGAS, TLR9, and ALRs guardians of the cellular galaxy against host-derived self-DNA

V Kumar - Frontiers in Immunology, 2021 - frontiersin.org
The immune system has evolved to protect the host from the pathogens and allergens
surrounding their environment. The immune system develops in such a way to recognize …

Design and characterization of immune-stimulating imidazo [4, 5-c] quinoline antibody-drug conjugates

S Fang, BM Brems, EO Olawode, JT Miller… - Molecular …, 2022 - ACS Publications
Traditional antibody-drug conjugate (ADC) technology has employed tumor-targeting
antibodies to selectively deliver ultrapotent cytotoxins to tumor tissue. While this technology …

[HTML][HTML] Cell-membrane-coated nanoparticles for the fight against pathogenic bacteria, toxins, and inflammatory cytokines associated with sepsis

X Wang, Z **a, H Wang, D Wang, T Sun, E Hossain… - Theranostics, 2023 - ncbi.nlm.nih.gov
Sepsis is the main cause of death in patients suffering from serious illness. Yet, there is still
no specific treatment for sepsis, and management relies on infection control. Cell membrane …